ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2026
Genetic mapping identifies QTL and candidate genes including Mendel's A gene controlling high levels of partial resistance to Fusarium avenaceum in Pea.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
key messageFav-Ps2.1 is the first major QTL reported for Fusarium avenaceum resistance in pea and co-localizes with Mendel's A gene and putative resistance genes. A novel moderate-effect QTL Fav-Ps5.1 and one epistatic locus, independent of the A gene, were also reported. Flavonoid compounds associated with resistance to this pathogen were identified. Fusarium avenaceum, a necrotrophic soil-borne pathogen, is a member of the root rot pathogen complex posing a major threat to pea yield and quality worldwide. Strong resistance to Fusarium root rot (FRR) in pea is associated with seed coat and flower pigmentation, controlled by Mendel's A locus regulating anthocyanin biosynthesis. It is not clear whether the A locus is acting alongside resistance genes to confer high levels of resistance or whether alternative genetic pathways exist in pea cultivars. In this study, a pea recombinant inbred line population of 160 lines called PR-20 (AA×aa), polyphenolic profiles, and the pea reference genome were leveraged to understand the genetic control of Fusarium avenaceum resistance. Two novel quantitative trait loci (QTLs) including a major QTL Fav-Ps2.1 (41-42.2 cM) on chromosome 6 with 95% phenotypic variance explained (PVE), a moderate-effect QTL Fav-Ps5.1 (126-134 cM) on chromosome 3 with 9% PVE, and a putative epistatic interaction with 15% PVE, associated with resistance to F. avenaceum were identified. Both the epistatic region and Fav-Ps5.1 are anthocyanin pigment-independent. Fav-Ps5.1 is co-localized with many defense-response and flavonoid-related genes including NDR1/HIN1-like protein, WDR, MYB111, WRKY, Chitinase, PAL1, F-box/LRR-repeat protein, E3 ubiquitin-protein ligase PUB22, ABC transporters, and probable ethylene response sensor 1. Fav-Ps2.1 is co-localized with 35 disease resistance-related genes and overlaps with the A locus, which may explain the high PVE. A 'pea tobacco mosaic virus (TMV) resistance N-like protein' gene, encoding TIR-LRR domains, marks the peak of Fav-Ps2.1 at ~ 0.12 cM upstream of the A locus. Regression analysis with whole seed polyphenolic compounds in randomly selected 14 PR-20 lines including the parents showed that some colorless flavonoids (anthocyanin precursors), encoded by genes other than A, explained more variation in disease resistance (R
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