Evidence map›Paper›PMID 42632866›Full record

ArticleCancer gene therapy2026

E-cadherin-driven interleukin-6 expression promotes autophagy-mediated platinum resistance in ovarian clear cell carcinoma.

Chiao-Yun Lin, An-Shine Chao, Shih-Ming Jung, Ren-Chin Wu, Ting-Chang Chang, Yun-Shien Lee, Yun-Hsin Tang, Shih-Sin Huang, Angel Chao, Chyong-Huey Lai

Abstract read
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Article in Cancer gene therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Chiao-Yun LinDepartment of Medical Research, Chang Gung Memorial Hospital at Linkou, Guishan District, Taoyuan, Taiwan.
An-Shine ChaoDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Guishan District, Taoyuan, Taiwan.
Shih-Ming JungDepartment of Pathology, Chang Gung Memorial Hospital at Linkou and Chang Gung University, College of Medicine, Guishan District, Taoyuan, Taiwan.
Ren-Chin WuDepartment of Pathology, Chang Gung Memorial Hospital at Linkou and Chang Gung University, College of Medicine, Guishan District, Taoyuan, Taiwan.
Ting-Chang ChangDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Guishan District, Taoyuan, Taiwan.
Yun-Shien LeeDepartment of Biotechnology, Ming-Chuan University, Guishan District, Taoyuan, Taiwan.
Yun-Hsin TangDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Guishan District, Taoyuan, Taiwan.
Shih-Sin HuangDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Guishan District, Taoyuan, Taiwan.
Angel ChaoDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Guishan District, Taoyuan, Taiwan. angel945@cgmh.org.tw.ORCID http://orcid.org/0000-0003-3834-2754
Chyong-Huey LaiDepartment of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Guishan District, Taoyuan, Taiwan. laich46@cgmh.org.tw.ORCID http://orcid.org/0000-0002-9977-9645

Funding

Chang Gung Memorial Hospital, Linkou (Linkou Chang Gung Memorial Hospital) CORPG1P0051Chang Gung Memorial Hospital, Linkou (Linkou Chang Gung Memorial Hospital) OMRPG3Q0021Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) NSTC 112-2320-B-182A-007 and NSTC 114-2629-B-182A-001-
6 · The paper itself

Abstract

Ovarian clear cell carcinoma (OCCC) is a distinct histological subtype of epithelial ovarian cancer that frequently exhibits chemotherapy resistance and poor outcomes. We investigated the regulatory role of E-cadherin signaling in driving interleukin-6 (IL-6) expression and promoting autophagy-dependent cisplatin resistance. In epithelial-like OCCC cell lines, elevated E-cadherin expression enhanced cisplatin resistance through β-catenin-mediated IL-6 transcription. Proteomic analysis of matched primary and recurrent OCCC specimens revealed upregulation of autophagy signaling in recurrent tumors. Immunoprecipitation confirmed direct interaction between IL-6 and sequestosome-1 (SQSTM1/p62) via its PB1 domain. In cisplatin-refractory patient-derived xenografts, IL-6 blockade significantly inhibited tumor growth. Clinically, in a cohort of 70 OCCC patients, increased serum IL-6 levels correlated with elevated CA125 (p < 0.001), recurrence (p < 0.001), advanced tumor stage (p = 0.014), and worse survival outcomes. High serum IL-6 was independently associated with shorter progression-free survival (p = 0.005). Collectively, these findings identify the E-cadherin/IL-6/autophagy axis as a key mediator of platinum resistance.

Indexed as

Adenocarcinoma, Clear CellAntigens, CDCadherinsDrug Resistance, NeoplasmInterleukin-6Ovarian NeoplasmsAnimalsAutophagyCell Line, TumorCisplatinFemaleGene Expression Regulation, NeoplasticHumansMiceAntigens, CDCadherinsCDH1 protein, humanCisplatinIL6 protein, humanInterleukin-6

Identifiers

PMID42632866

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.