Observational studyJournal of neurology2026
Beyond amnesia: neuropsychological deficits in acute unilateral posterior cerebral artery infarction involving the hippocampus.
Observational study in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute unilateral posterior cerebral artery (PCA) infarction involving the hippocampus can cause clinically relevant cognitive impairment, yet the acute neuropsychological syndrome remains insufficiently defined.
methodsThis retrospective observational study included 78 patients with unilateral PCA stroke involving the hippocampus who underwent assessment at a median of 5 days (IQR, 3-7 days) after symptom onset. Thirty-two patients had right-hemispheric and 46 had left-hemispheric infarctions. Cognitive symptoms at onset, structured behavioral observations, standardized clinical tasks, and formal norm-referenced neuropsychological testing were used to characterize impairment across cognitive domains. Group differences were examined, and multivariable logistic regression analyses were performed to identify predictors of cognitive dysfunction.
resultsNeuropsychological deficits involved memory, language, attention, executive functions, and visuoconstructive performance, indicating a broad range of cognitive symptoms rather than an isolated amnestic disturbance. Left-hemispheric infarctions were more often associated with amnestic symptoms at onset, and aphasic symptoms occurred exclusively in this group. Compared with right-sided lesions, left-hemispheric infarctions showed higher rates of subjective memory complaints and objective impairment in episodic memory, language production, and comprehension. Formal testing further demonstrated more frequent deficits in naming, categorical word fluency, verbal recall, verbal recognition, and visual recall. In multivariate analyses, lesion side emerged as the main predictor of neuropsychological impairment, whereas additional thalamic ischemia did not significantly improve prediction. DISCUSSION: Acute unilateral PCA infarction involving the hippocampus is associated with multidomain and possibly network-mediated early cognitive dysfunction with more extensive impairment after left-hemispheric lesions independent of thalamic involvement.
Indexed as
Identifiers
42632833What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.