ArticleScientific reports2026
Carotid plaque burden and hemodynamic alterations are associated with domain-specific cognitive impairment in community-dwelling older adults.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Carotid atherosclerosis has been linked to cognitive decline, but evidence regarding its association with domain-specific cognitive performance in understudied non-Western populations remains limited. We investigated the associations of carotid plaque burden and hemodynamic markers with cognitive impairment in 100 community-dwelling Egyptian adults aged ≥ 60 years without prior neurological disease. Carotid plaque burden was quantified by duplex ultrasound using plaque score, and cognition was assessed using the Montreal Cognitive Assessment (MoCA). Sixty-one Participants with a MoCA score ≤ 25 were classified as having possible mild cognitive impairment (MCI). Carotid plaques were detected in 53 participants, and plaque scores were higher in participants with possible MCI (p = 0.035). Internal carotid artery resistive index (ICA RI) was also higher (p = 0.011) among participants with possible MCI. In two separate multivariable models, plaque score (OR 1.41, 95% CI 1.06-1.86; p = 0.020) and ICA RI (OR 1.87, 95% CI 1.01-3.46; p = 0.046) were independently associated with possible MCI. Lower educational attainment showed the strongest association in both models. Plaque burden was most strongly associated with visuospatial and language performance. This cross-sectional study supports further longitudinal studies to determine whether carotid ultrasound markers predict subsequent cognitive decline.
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