Evidence map›Paper›PMID 42632170›Full record

ArticleEcotoxicology and environmental safety2026

The interplay of air pollution with plasma neurodegenerative markers and metabolome for dementia, Parkinson's disease and all-cause mortality risks and transitions: The UK Biobank study.

May A Beydoun, Tianyi Huang, Yi-Han Hu, Jordan Weiss, Michael F Georgescu, Nicole Noren Hooten, Marie T Fanelli-Kuczmarski, Hind A Beydoun, Minkyo Song, Lenore J Launer and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ecotoxicology and environmental safety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

May A BeydounLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, 251 Bayview Blvd, Baltimore, MD 21224, USA. Electronic address: baydounm@mail.nih.gov.
Tianyi HuangLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Yi-Han HuLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Jordan WeissOptimal Aging Institute, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA; Division of Precision Medicine, Department of Medicine, New York University Grossman School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Michael F GeorgescuLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Nicole Noren HootenLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Marie T Fanelli-KuczmarskiLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Hind A BeydounVA National Center on Homelessness Among Veterans, US. Department of Veterans Affairs, 810 Vermont Avenue NW, Washington, DC 20420, USA; Department of Management, Policy, and Community Health, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler Street, Houston, TX 77030, USA.
Minkyo SongLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Michele K EvansLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, 251 Bayview Blvd, Baltimore, MD 21224, USA.

Funding

Healthy Aging Neighborhoods of Diversity Across LifespanZ01AG000513 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2001 to 2008
$6.8M
Intramural NIH HHS Z01 AG000513
6 · The paper itself

Abstract

We investigated the joint associations of circulating neurodegeneration markers-neurofilament light (NfL) and glial fibrillary acidic protein (GFAP)-ambient air pollution, and plasma metabolomic profiles with transitions from a healthy state to dementia, Parkinson's disease (PD), and all-cause mortality in the UK Biobank. The analytic sample included 19,645 participants aged ≥ 50 years with complete proteomic, metabolomic, and environmental data. Time-to-event analyses used Cox proportional hazards and multistate Weibull models to evaluate associations and statistical interactions across health transitions. Higher NfL concentrations were associated with increased risks of transitions from healthy to PD, dementia, and death, whereas higher GFAP concentrations were specifically associated with dementia (HR = 2.65, 95% CI: 2.17-3.25). At the nominal level, particulate matter (PM

Indexed as

Air PollutantsAir PollutionDementiaMetabolomeParkinson DiseaseAgedBiomarkersFemaleGlial Fibrillary Acidic ProteinHumansMaleNeurofilament ProteinsParticulate MatterUK BiobankUnited KingdomAir PollutantsBiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament ProteinsParticulate MatterAir pollutionDementiaGlial Fibrillary Acidic ProteinMetabolomeNeurofilament LightParkinson’s Disease, All-cause mortality, multistate models, Aging

Identifiers

PMID42632170
PMCPMC13573725

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.