Evidence map›Paper›PMID 42632080›Full record

ArticleRedox report : communications in free radical research2026

A novel curcumin analog sAc15 alleviates LPS-induced acute lung injury by activating the PI3K/AKT/Nrf2 pathway in pulmonary epithelial cells.

Liqin Zhou, Zhiyi Tang, Yuting Lin, Tengfei Zhou, Mengya Shen, Yuxi Lin, Chengshui Chen, Chaolei Chen

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In one paragraph

Article in Redox report : communications in free radical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liqin ZhouDepartment of Pulmonary and Critical Care Medicine, Zhejiang Provincial Key Laboratory of Interventional Pulmonology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Zhiyi TangDepartment of Pulmonary and Critical Care Medicine, Zhejiang Provincial Key Laboratory of Interventional Pulmonology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yuting LinDepartment of Pulmonary and Critical Care Medicine, Zhejiang Provincial Key Laboratory of Interventional Pulmonology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Tengfei ZhouDepartment of Physiology, Zhejiang University School of Medicine, Hangzhou, China.
Mengya ShenDepartment of Pharmacy, Jiaxing Maternity and Child Health Care Hospital, Affiliated Women and Children's Hospital of Jiaxing University, Jiaxing, China.
Yuxi LinDepartment of Pulmonary and Critical Care Medicine, Zhejiang Provincial Key Laboratory of Interventional Pulmonology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Chengshui ChenDepartment of Pulmonary and Critical Care Medicine, Zhejiang Provincial Key Laboratory of Interventional Pulmonology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Chaolei ChenDepartment of Pulmonary and Critical Care Medicine, Zhejiang Provincial Key Laboratory of Interventional Pulmonology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAcute lung injury (ALI) is driven by oxidative stress and disrupted redox homeostasis. While curcumin is a potent natural antioxidant, its clinical application is limited. We evaluated the protective capacity and underlying mechanisms of sAc15, a stable curcumin analog, in ALI models.

methods

resultssAc15 exhibited broader safety margins and superior ROS suppression compared to natural curcumin. SPR established direct binding between sAc15 and recombinant Nrf2 (KD = 2.68 μM).

conclusionsAc15 ameliorates ALI by activating the PI3K/AKT/Nrf2 axis to restore oxidative equilibrium, hightlighhting its promise as a therapeutic candidate for ALI/ARDS.

Indexed as

Acute Lung InjuryCurcuminEpithelial CellsNF-E2-Related Factor 2Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAnimalsAntioxidantsApoptosisCell LineHumansLipopolysaccharidesLungMaleMiceMice, Inbred C57BLAntioxidantsCurcuminLipopolysaccharidesNF-E2-Related Factor 2Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReactive Oxygen SpeciesAcute lung injuryapoptosiscurcumin analogepithelial cellsmitochondrial dysfunctionNuclear factor erythroid 2-related factor 2 (Nrf2)oxidative stressPI3K/AKT pathway

Identifiers

PMID42632080
PMCPMC13501739

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.