ArticleInternational journal of circumpolar health2026
Effectiveness of coronavirus disease 2019 (COVID-19) original vaccines to prevent COVID-19-related hospitalisations among Alaska Native peoples, January 2021-October 2022.
Article in International journal of circumpolar health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
American Indian/Alaska Native (AI/AN) peoples experienced some of the highest rates of coronavirus disease 2019 (COVID-19) disease in the United States. However, there are limited data on COVID-19 vaccine effectiveness in this population. We performed a test-negative case‒control study using electronic health record data to evaluate the effectiveness of the original three FDA-authorised vaccines to prevent COVID-19-associated hospitalisations among AI/AN adults during 2021-2022. COVID-19 vaccines were effective in preventing COVID-19-associated hospitalisation, intensive care unit admission, mechanical ventilation and death in this population. However, vaccine effectiveness waned over time and during the post-Omicron variant time period. Booster vaccination proved effective during a period when the Omicron variant was circulating. Waning effectiveness with time and the introduction of new variants supports the need to stay up-to-date with SARS-CoV-2 vaccination. Evaluating vaccine effectiveness using electronic health records proved to be a useful tool during a pandemic.
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