ArticleSTAR protocols2026
Protocol to study recurrence of Clostridioides difficile infection in murine model with built-in colonization and contamination controls.
Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
3 authors.
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Abstract
Pre-colonization with endogenous murine Clostridioides difficile strains and cross-contamination between animals can compromise recurrent C. difficile infection (R-CDI) studies. We present a murine R-CDI protocol with built-in colonization and contamination controls. Mice receive an antibiotic cocktail and clindamycin before challenge with C. difficile spores, followed by vancomycin to induce recurrence. Selective cycloserine-cefoxitin-fructose agar (CCFA)/taurocholate-CCFA (TCCFA) fecal cultures quantify colonization, while PCR ribotyping identifies endogenous contaminants as a quality control. A two-handler workflow minimizes cross-contamination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.