TMS-Diazomethane-Mediated Thione Dimerization Enables Access to Photoconvertible Diazaxanthilidene Dyes for Live-Cell Imaging.

Joao Luiz P de Albuquerque, Christopher L Johnny, Leah G Raizen, Maria Ribagorda, David M Chenoweth

Abstract read

In one paragraph

Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Joao Luiz P de AlbuquerqueChemistry Department, University of Pennsylvania, 231 S 34th Street, Philadelphia19104, Pennsylvania, United States.ORCID 0009-0003-3091-1796

Christopher L JohnnyChemistry Department, University of Pennsylvania, 231 S 34th Street, Philadelphia19104, Pennsylvania, United States.

Leah G RaizenChemistry Department, University of Pennsylvania, 231 S 34th Street, Philadelphia19104, Pennsylvania, United States.

Maria RibagordaDepartamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid (UAM), 28049, Madrid, Spain.ORCID 0000-0001-7185-4095

David M ChenowethChemistry Department, University of Pennsylvania, 231 S 34th Street, Philadelphia19104, Pennsylvania, United States.ORCID 0000-0002-0819-4669

Funding

Tumor cell instrinsic DNA damage signaling to the immune responseP01CA265794 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Roger A Greenberg · 2023 to 2026

$8.5M

Agencia Estatal de Investigaci?n PID2023-146801NB-C32Fulbright Program NAMinisterio de Ciencia, Innovaci?n y Universidades PID2023-146801NB-C32NCI NIH HHS P01 CA265794NCI NIH HHS P01-CA265794University of Pennsylvania NA

6 · The paper itself

Abstract

Diazaxanthilidene dyes are photoconvertible small-molecule fluorophores with applications in live-cell imaging. Synthetic access has been limited by challenging dimerization reactions required to construct the sterically hindered tetrasubstituted olefin core. Herein, we report a TMS-diazomethane-mediated thione dimerization, and key intermediate, that enables rapid access to this framework at room temperature. The method provides new methyl-substituted diazaxanthilidene derivatives, including sterically hindered scaffolds that retain photoconvertible behavior and compatibility with live-cell imaging applications.

Indexed as

AlkenesDiazomethaneFluorescent DyesDimerizationMolecular StructurePhotochemical ProcessesAlkenesDiazomethaneFluorescent Dyes

Identifiers

PMID42632009

DOI10.1021/acs.orglett.6c02984

PMCPMC13505292

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.