ArticleThe Journal of organic chemistry2026
Room-Temperature Oxidative Cyclization of Carboxylic Acids Promoted by Copper(II) Trifluoromethanesulfonate and Selectfluor.
Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Room-Temperature Oxidative Cyclization of Carboxylic Acids Promoted by Copper(II) Trifluoromethanesulfonate and Selectfluor.The Journal of organic chemistry · 2026Article
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Authors and funding
1 author.
Funding
Abstract
We describe a room-temperature oxidative cyclization of carboxylic acids into γ- and δ-lactone products. First, a carboxylic acid substrate is stirred with copper(II) trifluoromethanesulfonate, Selectfluor, and potassium tert-butoxide in acetonitrile. With some substrates, lactone products are formed almost exclusively, but with others, significant amounts of overoxidized ketone side products are observed. Fortunately, these ketone products can be converted into the desired lactones by adding sodium borohydride and then 1 M aqueous hydrochloric acid solution to the cyclization flask. The reaction is scalable, can be run in the presence of air and ambient moisture, and gives useful lactone products.
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Registered trials
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