Evidence map›Paper›PMID 42631915›Full record

SynthesisBJS open2026

Pancreatic surgery and length of hospital stay: meta-analysis of randomized clinical trials.

Laetitia Z Hampe, Klaudia Narbekovas, Chenchen Li, Amila Cizmic, Anas A Preukschas, Anna Nießen, Jan Bardenhagen, Faik G Uzunoglu, Ulla Klaiber, Oliver Strobel and 4 more

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BJS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Laetitia Z HampeDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Klaudia NarbekovasDivision of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Chenchen LiDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Amila CizmicDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-0925-2330
Anas A PreukschasDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anna NießenDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jan BardenhagenDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Faik G UzunogluDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ulla KlaiberDivision of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-9287-1174
Oliver StrobelDivision of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.
Pascal ProbstDepartment of Surgery, Cantonal Hospital Thurgau, Frauenfeld, Switzerland.
Thilo HackertDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-7012-1196
Felix NickelDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-6066-8238
Carl-Stephan LeonhardtDivision of Visceral Surgery, Department of General Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0009-0001-7179-9580

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLength of hospital stay (LOS) is a commonly reported postoperative outcome measure in pancreatic surgery. However, LOS may be influenced by various factors, including healthcare systems, cultural traditions, and readmission rate. This systematic review and meta-analysis investigated LOS in pancreatic surgery.

methodsA meta-analysis was conducted to identify all randomized clinical trials (RCTs) of pancreatic surgery reporting LOS. Analyses were conducted using a random-effects model with mean differences as the effect estimator for the continuous outcome LOS.

resultsIn all, 186 RCTs published between 1994 and 2025, comprising 28 381 patients, were included. The mean LOS differed significantly by type of resection (P = 0.003) and by country (P < 0.001). Country remained a statistically significant factor after adjusting for readmission rate, year of study, and type of resection. The shortest LOS was observed in the USA, with a pooled value of 11 days (95% confidence interval (c.i.) 9.93 to 12.32) and the longest was seen in Japan, with a pooled value of 28 days (95% c.i. 25.60 to 31.67). Subgroup analysis of studies comparing minimally invasive and open surgery showed a mean LOS difference of 2 days (95% c.i. -2.79 to -0.85; prediction interval -7.70 to 4.06). However, this effect varied across countries, with mean LOS differences ranging from 1 to 6 days.

conclusionLOS after pancreatic surgery exhibited substantial statistical heterogeneity based on country, the type of operation, and access. This highlights the importance of considering contextual factors when evaluating and comparing LOS as an outcome measure in pancreatic surgery.

Indexed as

Length of StayPancreasPancreatectomyHumansPancreaticoduodenectomyRandomized Controlled Trials as Topic

Identifiers

PMID42631915
PMCPMC13499424

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.