Trial reportClinical oral investigations2026
Impact of reducing aligners' wear schedule from 7-days to 3-days on the predictability of tooth movement and treatment efficiency: a randomized controlled trial.
Trial report in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The trial behind it
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Authors and funding
8 authors.
Funding
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Abstract
TRIAL
designThis was a two-arm, parallel-group, single-blinded, single-center prospective randomized controlled trial conducted between October 2023 and March 2025.
participantsThirty-eight adults aged 18-30 years with Class I malocclusion and moderate-to-severe mandibular anterior crowding were included, recruited from a university orthodontic clinic. Forty-five participants were initially randomized; seven were excluded due to non-compliance.
interventionsParticipants were randomly assigned to a 3-day aligner wear protocol with reduced activation (0.11 mm/1° per tray) or a conventional 7-day protocol (0.25 mm/2° per tray).
objectiveTo evaluate the impact of reducing the aligner wear schedule from 7 days to 3 days on the predictability of linear and angular tooth movements for the mandibular incisors. OUTCOME: The primary outcome was the deviation between predicted and achieved mandibular incisors' tooth movement following the first aligner series, assessed across three linear and three angular dimensions. RANDOMIZATION: Participants were allocated using fixed block randomization with concealed sequentially numbered envelopes. BLINDING: Outcome assessors were blinded to group allocation.
resultsLinear deviations were comparable between groups and within the 0.5 mm ABO clinical threshold. Statistically significant angular deviations were observed for teeth 31 (p = 0.040) and 41 (p = 0.003), with additional significant buccolingual inclination for tooth 41 (p = 0.005); none exceeded the 2° clinical threshold. The 3-day group required significantly more refinement and clinical visits. No significant differences were observed in overall treatment duration or final occlusal outcomes. No adverse effects were reported.
conclusionsWhile both protocols produced comparable occlusal outcomes, the 3-day protocol required more refinements and visits without improved predictability, suggesting wear duration plays a key role in aligner effectiveness.
trial registrationClinicalTrials.gov xxxx.
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