ReviewTissue engineering and regenerative medicine2026
Effects of Cryopreservation on Stromal Vascular Fraction Viability in Human Adipose Tissue: Insights from a Systematic Review.
Review in Tissue engineering and regenerative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
backgroundCryopreservation of human adipose tissue facilitates long-term storage and repeated clinical application in tissue engineering and regenerative medicine. However, its quantitative impact on stromal vascular fraction (SVF) viability remains inconsistently characterized across studies with heterogeneous reporting formats. This study systematically evaluated the effect of cryopreservation on SVF viability and key procedural and donor-related determinants influencing post-thaw preservation quality.
methodsA systematic search of PubMed, Scopus, Web of Science, Cochrane Library, and ScienceDirect (January 2008-January 2025) identified in vitro and in vivo studies assessing cryopreserved human adipose tissue. Methodological quality was evaluated using the Joanna Briggs Institute (JBI) critical appraisal tools. Quantitative synthesis included a meta-analytic pooling of available comparable datasets alongside exploratory correlation analyses to examine associations between cryopreservation parameters and SVF viability.
resultsSeventeen studies met inclusion criteria, with six eligibles for quantitative meta-analysis. Pooled SVF viability was 0.062 × 10
conclusionCryopreservation preserves SVF viability at levels broadly comparable to fresh tissue, likely due to methodological variability across studies rather than true biological superiority in regenerative capacity. Post-thaw SVF quality is influenced more by cumulative processing and storage conditions than by freezing temperature alone. However, standardization of protocols and incorporation of functional potency assays beyond viability metrics are still essential to optimize clinical adipose tissue biobanking.
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