Evidence map›Paper›PMID 42631736›Full record

ReviewPediatric radiology2026

Skeletal dysplasias of the parathyroid hormone signaling cascade: radiological manifestations and molecular mechanisms.

Yuko Tsujioka, Atsuhiko Handa, Alistair D Calder, Denise P Cavalcanti, Ekkehart Lausch, Ok Hwa Kim, Tomonobu Hasegawa, Chikahiko Numakura, Masahiro Jinzaki, Gen Nishimura and 2 more

Erratum issuedAbstract readReview
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In one paragraph

Review in Pediatric radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yuko TsujiokaDepartment of Radiology, Keio University School of Medicine, Tokyo, Japan. yuko.tsujioka@keio.jp.
Atsuhiko HandaDepartment of Radiology, Boston Children's Hospital, Boston, United States.ORCID https://orcid.org/0000-0001-6401-4629
Alistair D CalderRadiology Department, Great Ormond Street Hospital NHS Foundation Trust, London, WC1N 3JH, United Kingdom. Alistair.Calder@gosh.nhs.uk.
Denise P CavalcantiDepartment of Translational Medicine-Area of Medical Genetics, State University of Campinas, São Paulo, Brazil.
Ekkehart LauschPediatric Genetics, Center for Pediatric and Adolescent Medicine, University Hospital Freiburg, Freiburg, Germany.
Ok Hwa KimDepartment of Radiology, VIC 365 Children's Hospital, Incheon, Republic of Korea.
Tomonobu HasegawaDepartment of Pediatrics, Keio University School of Medicine, Tokyo, Japan.
Chikahiko NumakuraDepartment of Genomic Medicine, Saitama Medical University Hospital, Iruma, Japan.
Masahiro JinzakiDepartment of Radiology, Keio University School of Medicine, Tokyo, Japan.
Gen NishimuraDepartment of Radiology, Musashino-Yowakai Hospital, Tokyo, Japan.
Carlos R FerreiraUnit on Skeletal Genomics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, United States.
Stephen P RobertsonDepartment of Paediatrics and Child Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.ORCID https://orcid.org/0000-0002-5181-7809

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent classification of skeletal dysplasias has reclassified disorders according to their underlying pathophysiologic mechanisms. The latest nosology of skeletal dysplasias introduced a new pathogenic category termed "skeletal disorders of the parathyroid hormone (PTH) signaling cascade." The group encompasses genetic defects associated with abnormal signaling of PTH, PTH-related protein (PTHrP) encoded by the PTHLH (PTH-like hormone) gene, and their common receptor termed parathyroid hormone 1 receptor (PTH1R). PTH1R is a guanine nucleotide-binding protein (G protein)-coupled receptor; and thus, defects of the a-subunit of stimulatory G protein (G

Indexed as

Bone dysplasiaEiken syndromeMetaphyseal dysplasia Jansen typeParathyroid hormoneParathyroid hormone 1 receptorParathyroid hormone-related peptidePseudohypoparathyroidismStimulatory G protein alpha subunit

Identifiers

PMID42631736

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.