ArticleJournal of applied physiology (Bethesda, Md. : 1985)2026
Sex comparison of cerebrovascular reactivity to CO
Kaylin D Didier, Logan J Heenan, Hedyeh Khademi Motlagh, Travis L Haley, Andrés R Ortiz, Jessica D Muer, Emily M Rogers, Brett M Wannebo, Marlowe W Eldridge, Oliver Wieben and 1 more
Abstract readComparative Study
In one paragraphArticle in Journal of applied physiology (Bethesda, Md. : 1985), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Kaylin D DidierDepartment of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0002-0281-8493 Logan J HeenanDepartment of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0009-0008-9591-0440 Hedyeh Khademi MotlaghDepartment of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Travis L HaleyDepartment of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Andrés R OrtizDepartment of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Jessica D MuerDepartment of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Emily M RogersDepartment of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0003-2643-2904 Brett M WanneboDepartment of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0009-0003-4201-7791 Marlowe W EldridgeDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0003-3636-1679 Oliver WiebenDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0002-7931-1930 William G SchrageDepartment of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0002-4674-1344 Funding
WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7MUniversity of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9MWaisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5MHuman cerebral blood flow regulation: sex, mechanism, and stress differencesR01HL150361 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI SCHRAGE, WILLIAM G · 2020 to 2024
$3.0MHigh Performance Gradient System for Advanced Neuroimaging ResearchS10OD030415 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI ALEXANDER, ANDREW L · 2021 to 2021
$2.0MHHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) P50 HD105353HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR002373HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL150361HHS | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) S10 OD030415HHS | NIH | NIH Office of the Director (OD) P51OD011106NCATS NIH HHS UL1 TR002373NHLBI NIH HHS R01 HL150361NICHD NIH HHS P50 HD105353NIH HHS P51 OD011106NIH HHS S10 OD030415
6 · The paper itselfAbstract
Cerebrovascular and neurological diseases show sex-specific risks and regional variation, both of which are linked to changes in cerebral blood flow (CBF), suggesting that sex or sex hormones may influence cerebrovascular function. Cerebrovascular reactivity (CVR) to hypercapnia may help predict these outcomes, but the identification of fundamental sex differences in CVR remains equivocal. Most CVR studies use methods that cannot identify regional variation, which may be clinically relevant. This study examined whether sex differences exist in CVR at the whole brain, lobular, and regional levels while controlling for confounding factors like menstrual cycle and hormonal contraception. Eighty-seven young, healthy adults (38 F, 49 M; F: 22 ± 4 yr, M: 23 ± 4 yr, 18-37 yr) from two similar cohorts were studied using pseudocontinuous arterial spin labeling (pcASL) in a 3 T magnetic resonance imaging (MRI) scanner to derive microvascular CBF at room air and during hypercapnia (∼+8 mmHg end-tidal CO
Indexed as
BrainCarbon DioxideCerebrovascular CirculationAdolescentAdultFemaleHumansHypercapniaMagnetic Resonance ImagingMaleMenstrual CycleSex CharacteristicsYoung AdultCarbon Dioxidecerebral blood flowcerebrovascular reactivityenvironmental stressmagnetic resonance imagingsex differences
Identifiers
PMID42631391
PMCPMC13600600
What OpenQuestion holds
Textmetadata
Read underepoch 390