Evidence map›Paper›PMID 42631305›Full record

ArticleJournal of community hospital internal medicine perspectives2026

IgG4-related Sclerosing Cholangitis Masquerading as Cholangiocarcinoma: A Diagnostic Challenge.

Shahem Abbarh, Bisher Sawaf, Radhika Vij, Kiyoko Oshima, Keiichi Kinowaki, Abhinav Sankineni

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of community hospital internal medicine perspectives, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shahem AbbarhDepartment of Internal Medicine, MedStar Health, Baltimore, MD, USA.
Bisher SawafDepartment of Internal Medicine, University of Toledo Medical Center, Toledo, OH, USA.
Radhika VijDepartment of Internal Medicine, MedStar Health, Baltimore, MD, USA.
Kiyoko OshimaDivision of Gastrointestinal Liver Pathology, Johns Hopkins University, Baltimore, MD, USA.
Keiichi KinowakiDivision of Gastrointestinal Liver Pathology, Johns Hopkins University, Baltimore, MD, USA.
Abhinav SankineniDepartment of Gastroenterology, MedStar Health, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: IgG4-related sclerosing cholangitis (IgG4-SC) is a rare immune-mediated disorder affecting the biliary tree and leading to biliary strictures that may resemble cholangiocarcinoma (CCA). Case presentation: An elderly man presented with a one-week history of jaundice, pale stool, and dark urine. This was associated with unintentional weight loss over the past year. Laboratory findings were notable for cholestasis and significantly elevated CA19-9. Imaging demonstrated multiple diffuse biliary strictures of malignant appearance. Cytology showed atypical glandular cells. The patient was misdiagnosed with CCA and was assessed for a possible surgical intervention or chemoradiotherapy. However, the patient was eventually diagnosed with IgG4-SC after a high serum IgG4 level and liver biopsy. The patient responded well to steroids. Conclusion: This case underscores the diagnostic dilemma posed by IgG4-SC, particularly in elderly patients with cholestatic jaundice and elevated CA 19-9, which can be misleading for malignancy.

Indexed as

CholangiocarcinomaIgG4-RDIgG4-SCObstructive jaundicePrimary sclerosing cholangitis

Identifiers

PMID42631305
PMCPMC13496465

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.