ArticleAmerican journal of translational research2026
Combined predictive accuracy of inflammatory and hematologic indicators for urinary tract-related bloodstream infection.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesUrinary tract-related bloodstream infection (UT-BSI) is a severe complication of hospital-acquired urinary tract infection (HA-UTI), yet its early diagnosis remains challenging. This study aimed to evaluate the combined predictive efficiency of inflammatory and hematologic indicators for UT-BSI.
methodsA retrospective analysis was conducted on patients with HA-UTI admitted to non-critical internal medicine wards between July 2023 and June 2025. Patients were categorized into bloodstream infection (BSI) and non-BSI groups based on positive blood cultures yielding pathogens identical to those isolated from urine samples. Within 6 hours of blood culture sampling, levels of interleukin-6 (IL-6), procalcitonin (PCT), C-reactive protein (CRP), white blood cell count (WBC), platelet count (PLT), and neutrophil-to-lymphocyte ratio (NLR) were measured.
resultsA total of 279 HA-UTI patients were enrolled for analysis, comprising 165 in the non-BSI group and 114 in the BSI group. The BSI group exhibited significantly elevated levels of IL-6 (36.74 vs. 28.36 pg/mL, P < 0.001), PCT (0.72 vs. 0.54 ng/mL, P < 0.001), CRP (50.56 vs. 38.18 mg/L, P < 0.001), WBC (12.43 vs. 11.59 × 10
conclusionsA predictive model combining inflammatory and hematologic indicators demonstrated superior predictive accuracy for UT-BSI and may serve as a practical tool for early clinical risk stratification.
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