ArticleAJOG global reports2026
Development of a clinical prediction model for pathological upgrade from endometrial atypical hyperplasia to endometrial cancer: a retrospective Eastern Chinese cohort study.
Article in AJOG global reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroudEndometrial cancer (EC), the most prevalent gynecologic malignancy in developed countries, often arises from endometrial atypical hyperplasia (EAH). Thus, how to predict EAH combined with EC before total hysterectomy is particularly important.
objectiveThis study aimed to identify preoperative predictors of pathological upgrade from EAH to EC and develop a clinical prediction model. STUDY
designThis retrospective cohort study analyzed 519 patients who underwent hysterectomy with EAH diagnosed on biopsy. Postoperative pathology classified patients into the EAH (n=413) or EC (n=106) group. Demographic, clinical, laboratory, and imaging data were compared. Multivariate logistic regression and ROC analyses identified risk factors and model performance.
resultsIn this study, 20.42% (106/519) of cases with EAH were confirmed as EC after hysterectomy. The number of EC patients with stage Ia, Ib, II, and III were 91 (85.85%), 10 (9.43%), 1 (0.94%), and 4 (3.78%), respectively. Lymph node metastasis was observed in 2.83% (3/106) of the patients. The EC group exhibited significantly higher mean age (51.44 vs 49.63 years,
conclusionWe established novel preoperative prediction models that integrates endometrial, metabolic, coagulation, inflammatory parameters, with the inclusion or exclusion of MRI features to identify co-existing endometrial carcinoma in atypical hyperplasia.
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