Magnetically responsive electrospun fibers as programmable bioactive scaffolds: From formulation design to magnetically triggered therapy and regeneration.

Ashish Trital, Burhan Ates, Ryan J Gilbert

Abstract readReview

In one paragraph

Review in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ashish TritalLinda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO, 65409, United States.

Burhan AtesLinda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO, 65409, United States.

Ryan J GilbertLinda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO, 65409, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetically responsive electrospun fibers (MREFs) represent an emerging class of active soft materials designed to control where, when, and how fast a therapeutic agent or biophysical cue is delivered. Unlike conventional electrospun fibers, whose release and mechanical behavior are fixed at fabrication, MREFs can be manipulated after implantation, using an applied magnetic field to generate localized heating, mechanical deformation, structural reorientation, magnetic guidance, or triggers thermoresponsive release. This review compares MREF compositions, fabrication strategies, and magnetothermal, magneto-mechanical, and magnetic-guidance mechanisms across applications in cancer therapy, tissue regeneration, wound healing, and theranostics and critically evaluates key translational barriers, safety, and regulatory requirements. Current evidence suggests that localized and surface-accessible treatments are the most realistic near-term clinical applications.

Indexed as

Alternating magnetic fieldBiomedical applicationControlled releaseElectrospinningHyperthermiaLocalized therapyMagnetic particles

Identifiers

PMID42631109

DOI10.1016/j.bioactmat.2026.08.014

PMCPMC13495609

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.