Evidence map›Paper›PMID 42630940›Full record

ArticleChemical science2026

Decarboxylative functionalization strategy for rapid assembly of bifunctional adamantane

Cade A MacAllister, Omar A Solis, Alexander J Reif, Nicole C Goodwin, Tehshik P Yoon

Abstract read
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cade A MacAllisterDepartment of Chemistry, University of Wisconsin-Madison 1101 University Avenue Madison WI 53706 USA tyoon@chem.wisc.edu.ORCID https://orcid.org/0000-0001-9689-6486
Omar A SolisDepartment of Chemistry, University of Wisconsin-Madison 1101 University Avenue Madison WI 53706 USA tyoon@chem.wisc.edu.ORCID https://orcid.org/0009-0002-9910-4055
Alexander J ReifDiscovery Chemistry, Molecular Modalities Discovery GSK Collegeville PA 19426 USA.ORCID https://orcid.org/0009-0004-3412-3129
Nicole C GoodwinDiscovery Chemistry, Molecular Modalities Discovery GSK Collegeville PA 19426 USA.
Tehshik P YoonDepartment of Chemistry, University of Wisconsin-Madison 1101 University Avenue Madison WI 53706 USA tyoon@chem.wisc.edu.ORCID https://orcid.org/0000-0002-3934-4973

Funding

SYNTHETIC PHOTOCHEMISTRYR35GM144129 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI TEHSHIK P YOON · 2022 to 2026
$3.1M
QExactive (Orbitrap) mass spectrometerS10OD020022 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI VESTLING, MARTHA M · 2015 to 2015
$483k
NIGMS NIH HHS R35 GM144129NIH HHS S10 OD020022
6 · The paper itself

Abstract

The use of rigid saturated bioisosteres as replacements for aromatic rings has emerged as a powerful strategy for improving the physiochemical and pharmacokinetic profiles of medicinal lead compounds. While significant progress has been made in developing surrogates for

Identifiers

PMID42630940
PMCPMC13494953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.