Trial reportDrug design, development and therapy2026
Effect of Intranasal Dexmedetomidine on the Night Before Surgery for Postoperative Delirium in Older Patients Undergoing Total Hip or Knee Arthroplasty: A Randomized Clinical Trial.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- On the Robustness of Preoperative Intranasal Dexmedetomidine for Postoperative Delirium Prevention: Methodological Considerations [Letter].Drug design, development and therapy · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Importance: Postoperative delirium is a common and serious neurocognitive complication in elderly arthroplasty patients, with preoperative poor sleep as a key risk factor. Effective preoperative prevention strategies remain an urgent clinical need. Objective: To assess preoperative intranasal dexmedetomidine for preventing postoperative delirium in older adults undergoing hip or knee arthroplasty. Design: This trial was conducted at a single tertiary academic hospital in China from January 10, 2025 to June 10, 2025, with follow-up assessments performed from admission to 7 days after surgery. Setting: This was a single-center, double-blind, placebo-controlled randomized trial. Participants: 232 elderly patients aged 60 years or older, with American Society of Anesthesiologists (ASA) status 1 to 3, scheduled for total hip or knee arthroplasty under general anesthesia were enrolled and randomized 1:1 after eligibility screening. Interventions: Intranasal dexmedetomidine(100 μg total dose) or normal saline, administered at 21:00 on the night before surgery. Main Outcomes and Measures: The primary outcome was the incidence of postoperative delirium within 3 postoperative days, evaluated by the Confusion Assessment Method. Secondary outcomes included postoperative delirium incidence within 7 days, duration, severity, subtype, perioperative sleep quality, pain, anxiety, quality of recovery, time to ambulation, and adverse events. Results: In the intention-to-treat analysis, the postoperative delirium incidence within 3 days was 10.3% in the dexmedetomidine group and 20.7% in the placebo group [relative risk=0.50; 95% confidence interval (CI)=0.26-0.95; Conclusion: Intranasal dexmedetomidine on the night before surgery could reduce the incidence of postoperative delirium and improve perioperative sleep quality in older patients undergoing joint arthroplasty. Sleep improvement may partly explain this association, suggesting a potential supportive strategy for delirium prevention. Trial Registration: Chinese Clinical Trial Registry Identifier: ChiCTR2500095414.
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