Snapshot Redox Cycling Voltammetry (Snapshot RCV): Fast Generation-Collection Detection across a Wide Potential Range at a Chip-Based Microelectrode Array.

During generation-collection, redox-active species oxidize (or reduce) at generator electrodes and electrochemically convert back at neighboring collector electrodes, yielding dual-current signals shaped by mass transport, reaction kinetics, and scaled by analyte concentration. As electrode spacing decreases, diffusion layers overlap, recycling species in a feedback loop (redox cycling, RC) and amplifying observed currents. While advantageous, conventional RC techniques experience challenges: chronoamperometry (CA) offers high temporal resolution but lacks thermodynamic insight, while cyclic voltammetry (CV) captures the potential window but is constrained by scan duration and background current at high speeds. Here, snapshot redox cycling voltammetry (Snapshot RCV) is introduced, which constructs the profile of a conventional RC voltammogram without a potential sweep. By simultaneously biasing individual generator electrodes in a microband array to different voltages across the potential range while individually holding collector electrodes at a reversing potential, high-resolution "spatial" voltammograms are obtained in as little as 1 s, providing steady-state generation-collection profiles on a chronoamperometric time scale. This method was evaluated using 0.50 mM Ru-(NH