Evidence map›Paper›PMID 42630839›Full record

ArticleJournal of the National Cancer Center2026

Epidemiological characteristics and risk factors of lung cancer in a population with incidental pulmonary nodules in China: a prospective multicenter study of 10,560 cases.

Wenhua Liang, Yongzhao Zhou, Chengping Hu, Wei Xiao, Jian Zhang, Min Li, Wei Wang, Xianwei Ye, Xiangyan Zhang, Ning Chang and 43 more

Abstract read
PubMed Full text at PMC Publisher
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Article in Journal of the National Cancer Center, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

53 authors.

Wenhua LiangDepartment of Thoracic Surgery/Oncology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Disease & Health, China State Key Laboratory and National Clinical Research Center for Respiratory Disease, Guangzhou, China.
Yongzhao ZhouDepartment of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, China.
Chengping HuDepartment of Respiratory Medicine, Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, China.
Wei XiaoDepartment of Respiratory Medicine, QILU Hospital, Shandong University, Jinan, China.
Jian ZhangDepartment of Pulmonary Medicine, Xijing Hospital, Air Force Medical University of PLA, Xi'an, China.
Min LiDepartment of Respiratory Medicine, Xiangya Cancer Center, Xiangya Hospital, Central South University, Changsha, China.
Wei WangDepartment of Respiratory Medicine, QILU Hospital, Shandong University, Jinan, China.
Xianwei YeDepartment of Respiratory and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, China.
Xiangyan ZhangDepartment of Respiratory and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, China.
Ning ChangDepartment of Pulmonary Medicine, Xijing Hospital, Air Force Medical University of PLA, Xi'an, China.
Chunmei YunNHC Key Laboratory of Diagnosis & Treatment of COPD, Inner Mongolia Key Laboratory of Respiratory Diseases, Inner Mongolia People's Hospital, Hohhot, China.
Dejun SunNHC Key Laboratory of Diagnosis & Treatment of COPD, Inner Mongolia Key Laboratory of Respiratory Diseases, Inner Mongolia People's Hospital, Hohhot, China.
Yunhui ZhangDepartment of Respiratory Medicine, The First People's Hospital of Yunnan Province, Kunming, China.
Zheng QinDepartment of Respiratory Medicine, The First Hospital of China Medical University, Shenyang, China.
Wei WangDepartment of Respiratory Medicine, The First Hospital of China Medical University, Shenyang, China.
Yong ZhangDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Xin ZhangDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Yi XiangDepartment of Pulmonary & Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jieming QuDepartment of Pulmonary & Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei ZhangDepartment of Respiration, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Longhua SunDepartment of Respiration, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Yang HuDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Jinfu XuDepartment of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Di WuDepartment of Pulmonary and Critical Care Medicine, Shenzhen Institute of Respiratory Diseases, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), The First Affiliated Hospital of Southern University of Science and Technology (Shenzhen People's Hospital), China.
Jianping ZhaoDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiaoju ZhangDepartment of Respiratory Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
Hairong BaoDepartment of Gerontol Respiratory Medicine, The Frist Hospital of Lanzhou University, Lanzhou, China.
Xiaoju LiuDepartment of Gerontol Respiratory Medicine, The Frist Hospital of Lanzhou University, Lanzhou, China.
Yubiao GuoDepartment of Pulmonary Medicine, The First Affiliated Hospital of Sun Yat Sen University, Guangzhou, China.
Zhanqing LiDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, China.
Qichuan ZhangDepartment of Respiratory and Critical Care Medicine, Shantou Central Hospital, Shantou, China.
Weiyi ZhuDepartment of Respiratory and Critical Care Medicine, Shantou Central Hospital, Shantou, China.
Lan YangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Xiaomin DangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Baohui HanDepartment of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China.
Zhaohui TongDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Feng WangDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Liping LiuDepartment of Clinical Laboratory, State Key Laboratory of Respiratory Disease and National Clinical Research Centre for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Minhua PengAnchorDx Medical Co., Ltd., Guangzhou, China.
Shuangxiu WuAnchorDx Medical Co., Ltd., Guangzhou, China.
Liuhong ZengAnchorDx Medical Co., Ltd., Guangzhou, China.
Lin TengAnchorDx Medical Co., Ltd., Guangzhou, China.
Xiangcheng QiuAnchorDx Medical Co., Ltd., Guangzhou, China.
Bo WangAnchorDx Medical Co., Ltd., Guangzhou, China.
Jinsheng TaoAnchorDx Medical Co., Ltd., Guangzhou, China.
Meng YangAnchorDx Medical Co., Ltd., Guangzhou, China.
Junjie ZhaoAnchorDx Medical Co., Ltd., Guangzhou, China.
Silvia S ChenInterventional Oncology at Johnson and Johnson, New Brunswick, United States.
Jianbing FanAnchorDx Medical Co., Ltd., Guangzhou, China.
Weimin LiDepartment of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, China.
Dan LiuDepartment of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, China.
Jianxing HeDepartment of Thoracic Surgery/Oncology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Disease & Health, China State Key Laboratory and National Clinical Research Center for Respiratory Disease, Guangzhou, China.
Nanshan ZhongNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lung cancer incidence and mortality continue to rise in China, highlighting the need for a deeper understanding of its epidemiology and optimal screening targets. Methods: A total of 10,560 participants with 5-30 mm pulmonary nodules incidentally detected via low-dose computed tomography (LDCT)/CT were enrolled from 23 hospitals (October 2018-May 2021) and followed for 2-3 years for evaluation of circulating tumor DNA (ctDNA) biomarkers to distinguish malignant and benign nodules. Demographic, clinical, and imaging data were collected and analyzed. Lung cancer risk factors were assessed using stepwise single and multiple-factor binary logistic regression. This study reports only the baseline epidemiological characteristics of the population and the associated risk factors of lung cancer. Results: A higher proportion of females (56.56%) were present across all age groups, with a median age of 53 years (45-62), younger than males (55 years [46-63], Conclusion: Our large-scale investigation provides updated data to guide future precise clinical management of pulmonary nodules, with a particular focus on younger females and reducing overtreatment.

Indexed as

Epidemiological characteristicsLung cancerPulmonary nodulesRisk factors

Identifiers

PMID42630839
PMCPMC13494645

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