Evidence map›Paper›PMID 42630800›Full record

ArticlePhysics and imaging in radiation oncology2026

Proton Bragg peak flash stereotactic radiosurgery for recurrent glioblastoma reirradiation.

Yangguang Ma, Yuyu Wang, Tengda Zhang, Xingyi Zhao, Balaji Selvaraj, Chingyun Cheng, Michael Pennock, Jocelyn Jackson, Wei Guo, Xuanqin Mou and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physics and imaging in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yangguang MaRadiotherapy Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Yuyu WangFaculty of Medical Sciences, University of Groningen, University Medical Center Groningen, the Netherlands.
Tengda ZhangDepartment of Radiation Medicine, University of Wisconsin-Madison, Madison, WI 53792, USA.
Xingyi ZhaoNew York proton center, New York, NY 10035, USA.
Balaji SelvarajNew York proton center, New York, NY 10035, USA.
Chingyun ChengDepartment of Radiation Medicine, University of Wisconsin-Madison, Madison, WI 53792, USA.
Michael PennockDepartment of Radiation Oncology, University of Pittsburgh Medical Center Hillman Cancer Center; University of Pittsburg Medical Center Beaver; Heritage Valley Health System, Pittsburgh, PA 15232, USA.
Jocelyn JacksonDepartment of Radiation Medicine, University of Wisconsin-Madison, Madison, WI 53792, USA.
Wei GuoRadiation Oncology, the Affiliated Cancer, Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450003, China.
Xuanqin MouSchool of Information and Communications Engineering, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
Benjamin DurkeeDepartment of Radiation Medicine, University of Wisconsin-Madison, Madison, WI 53792, USA.
Jehee Isabelle ChoiNew York proton center, New York, NY 10035, USA.
Haibo LinNew York proton center, New York, NY 10035, USA.
Charles B SimoneNew York proton center, New York, NY 10035, USA.
Minglei KangDepartment of Radiation Medicine, University of Wisconsin-Madison, Madison, WI 53792, USA.
Hui WuRadiation Oncology, the Affiliated Cancer, Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Purpose: Stereotactic Radiosurgery with robotic image-guided systems is promising for recurrent glioblastoma (rGBM), but long delivery times may increase morbidity and reduce accuracy. Proton single-energy Bragg-peak FLASH-RT (SEBP-FLASH) may address these limits by delivering each field in <1 s, with potential for normal-tissue sparing through the FLASH effect. Materials and Methods: The SEBP-FLASH technique was used to reoptimize treatment for rGBM patients treated with robotic image-guided systems. Patient-specific aperture devices were incorporated into the SEBP-FLASH technique for sharper penumbra. The gross tumor volume (GTV) coverage, conformity index (CI), dose gradient index (GI Results: SEBP-FLASH successfully met all clinical objectives. Both SEBP-FLASH and robotic techniques showed comparable performance, with GI Conclusions: This study evaluated the dose-volume characteristics of SEBP-FLASH and robotic image-guided systems and found broadly comparable dose distributions, suggesting that SEBP-FLASH may be a feasible option for rGBM reirradiation. SEBP-FLASH also showed potential advantages in conformity, normal tissue sparing, and reduced on-table time.

Indexed as

Bragg peak FLASHCyberKniferecurrent glioblastomareirradiationstereotactic radiosurgery

Identifiers

PMID42630800
PMCPMC13495584

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.