Evidence map›Paper›PMID 42630757›Full record

ArticlePatterns (New York, N.Y.)2026

Deep learning enabled prediction of nuclear lamina-associated chromatin.

Priyojit Das, Jeannie T Lee

Abstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Priyojit DasDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Jeannie T LeeDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.

Funding

Regulation of X-Inactivation by Non-Coding RNA LociR01GM058839 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, JEANNIE T · 1999 to 2025
$6.7M
NIGMS NIH HHS R01 GM058839
6 · The paper itself

Abstract

Tethering of chromatin regions to the nuclear lamina contributes to genome organization and gene regulation. Though several molecular and epigenomic determinants of lamina association have been studied, the influence of genomic sequences has received less attention. Here, we present lamina-associated domain finder (LADDER), a multimodal deep learning model to predict lamina association based on DNA sequence, gene density, and long interspersed nuclear element (LINE)1 and short interspersed nuclear element (SINE) densities. The predictions made by LADDER are cell-type independent. Using LADDER's predictive ability and performing

Indexed as

computational modelingCTCFdeep learninggene escapeHi-CLADlamina-associated domainsnuclear laminapolymer modelingradial organization

Identifiers

PMID42630757
PMCPMC13494609

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.