Evidence map›Paper›PMID 42630752›Full record

ArticleAdvances in ophthalmology practice and research

Anterior chamber depth and vitreous zonule integrity as biomarkers for intraoperative capsule laxity in angle closure.

Hui Zhang, Jin Wang, Yue Wang, Zijian Liu, Dongjun Li, Lin Shen, Chunyan Qiao, Ching-Yu Cheng, Ye Zhang

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Article in Advances in ophthalmology practice and research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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9 authors.

Hui ZhangBeijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Jin WangBeijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Yue WangBeijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Zijian LiuBeijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Dongjun LiBeijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Lin ShenBeijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Chunyan QiaoBeijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Ching-Yu ChengCentre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ye ZhangBeijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate preoperative predictors for anterior and posterior capsule laxity during phacoemulsification combined with anti-glaucoma surgery in eyes with angle closure. Methods: Cross-sectional study. Patients aged ≥40 years diagnosed with angle closure who underwent phacoemulsification combined with anti-glaucoma surgery between May 2023 and May 2025 were enrolled. Eyes were classified into four groups based on intraoperative findings: anterior capsule laxity, posterior capsule laxity, combined capsule laxity, and normal capsule. Mixed-effects logistic regression analysis was employed to determine the independent predictors of anterior and posterior capsule laxity, respectively. Results: A total of 241 eyes of 203 patients were included. 36 eyes (14.9%) had anterior laxity, 51 eyes (21.2%) had posterior laxity, 73 eyes (30.3%) had combined capsule laxity, and 81 eyes (33.6%) had normal capsule. Eyes with anterior laxity had shallower anterior chamber depth (ACD) than normal capsule eyes (2.05 (1.82,2.29) mm vs. 2.33 (2.13, 2.52) mm, Conclusions: APAC diagnosis and shallow ACD predict anterior capsule laxity, whilst VZ absence, APAC diagnosis, and increased CBMT indicate posterior capsule laxity in eyes with angle closure. Identification of these biomarkers before surgery may help surgeons anticipate complications and optimize postoperative outcomes.

Indexed as

Angle closureCapsule laxityPreoperative biomarkersVitreous zonule

Identifiers

PMID42630752
PMCPMC13495364

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