Evidence map›Paper›PMID 42630730›Full record

ArticleOncology research2026

MicroRNA320e Augments the Synthetic Lethality of Olaparib by Regulating the PI3K-AKT-mTOR Pathway.

Wei Zheng, Qianlong Meng, Yunhan Deng, Ruizhen Liu, Siyu Bai, Longyu Jia, Jing Wang, Huimin Bai

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Article in Oncology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Wei ZhengDepartment of Gynecology, Fuxing Hospital, Capital Medical University, Beijing, China.
Qianlong MengDepartment of Gynecology, Fuxing Hospital, Capital Medical University, Beijing, China.
Yunhan DengDepartment of Gynecology, Fuxing Hospital, Capital Medical University, Beijing, China.
Ruizhen LiuDepartment of Gynecology, Fuxing Hospital, Capital Medical University, Beijing, China.
Siyu BaiDepartment of Gynecology, Fuxing Hospital, Capital Medical University, Beijing, China.
Longyu JiaDepartment of Gynecology, Fuxing Hospital, Capital Medical University, Beijing, China.
Jing WangBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Huimin BaiDepartment of Gynecology, Fuxing Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesGiven the increasing drug resistance in ovarian cancer (OC), the use of poly ADP-ribose polymerase inhibitors (PARPi) for treating homologous recombination repair defects (HRD) has encountered new challenges. MicroRNA320e (miR-320e) exerts a negative regulatory role in the progression of multiple cancers. This study aimed to investigate the association between miR-320e and drug resistance in ovarian cancer.

methodsThe Cell Counting Kit-8 (CCK-8) assay, migration and invasion assays, and colony formation assay were employed to evaluate the proliferation, migration, and invasion abilities of cells. Western blot (WB) analysis was used to verify the expression levels of proteins related to the relevant signaling pathways in cells. The xenograft subcutaneous tumor model was established to investigate the effect of miR-320e on

resultsmiR-320e was overexpressed in both A2780 and SKOV3 cells. The results showed that transfection with miR-320e significantly reduced cell proliferation, invasion, and migration, while enhancing autophagy and apoptosis. Additionally, the PI3K-AKT-mTOR signaling pathway was significantly inhibited in the treatment groups. In nude mouse models, overexpression of miR-320e also significantly suppressed tumor growth. These findings indicate that overexpression of miR-320e enhances the sensitivity of OC cells to olaparib therapy.

conclusionIn conclusion, miR-320e overexpression significantly inhibits the malignancy of ovarian cancer and increases the sensitivity of ovarian cancer cells to olaparib.

Indexed as

MicroRNAsOvarian NeoplasmsPhosphatidylinositol 3-KinasesPhthalazinesPiperazinesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationDrug Resistance, NeoplasmFemaleGene Expression Regulation, NeoplasticHumansMicroRNAsMIRN320 microRNA, humanMTOR protein, humanolaparibPhosphatidylinositol 3-KinasesPhthalazinesPiperazinesPoly(ADP-ribose) Polymerase InhibitorsProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinasesfibronectin 1 (FN1)MicroRNA320e (miR-320e)olaparibPI3K-AKT-mTORpoly ADP-ribose polymerase inhibitors (PARPi)

Identifiers

PMID42630730
PMCPMC13494476

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.