Evidence map›Paper›PMID 42630686›Full record

ReviewOncology research2026

Targeting the Neuro-Immune Axis in Next-Generation Oncology: Discovery and Validation of β

Heng Xu, Jiaan Lu, Zizhang Wang, Jiayu Xu, Shihui Peng, Haiqing Chen, Qiang Cao, Qing Sun, Shangke Huang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oncology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Heng XuClinical Medical College, Southwest Medical University, Luzhou, China.
Jiaan LuClinical Medical College, Southwest Medical University, Luzhou, China.
Zizhang WangClinical Medical College, Southwest Medical University, Luzhou, China.
Jiayu XuSchool of Computer Science and Informatics, Cardiff University, Cardiff, UK.
Shihui PengDepartment of Public Health Laboratory Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China.
Haiqing ChenDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Qiang CaoFaculty of Applied Sciences, Macao Polytechnic University, R. de Luís Gonzaga Gomes, Macao, China.
Qing SunDepartment of Otolaryngology, QingPu Hospital Affiliated to Fudan University, Shanghai, China.
Shangke HuangDepartment of Oncology, The Affiliated Hospital, Southwest Medical University, Luzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the potential of current cancer immunotherapies, tumor cells frequently evade immune surveillance by forming an immunosuppressive microenvironment, leading to treatment resistance. Current inquiry positions the sympathetic nervous system (SNS) at the forefront of tumor immunology as a critical driver of this immune evasion. This review delineates the cellular pharmacology of SNS-mediated immune regulation across the tumor ecosystem. Operating predominantly through the cyclic adenosine monophosphate-protein kinase A (cAMP-PKA) signaling axis, the SNS engages in bidirectional regulation with immune cells of the tumor microenvironment (TME). Norepinephrine and epinephrine interact with β

Indexed as

Adrenergic beta-2 Receptor AntagonistsDrug Resistance, NeoplasmNeoplasmsReceptors, Adrenergic, beta-2Tumor MicroenvironmentAnimalsHumansImmunotherapySignal TransductionSympathetic Nervous SystemTumor EscapeAdrenergic beta-2 Receptor AntagonistsReceptors, Adrenergic, beta-2clinical translationimmunotherapy resistancemulti-omicsPredictive biomarkerssympathetic-immune axistumor ecosystemβ2-adrenergic receptor

Identifiers

PMID42630686
PMCPMC13494482

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.