Evidence map›Paper›PMID 42630654›Full record

ArticleAmerican journal of translational research2026

A novel Microtus fortis MCAO model for ischemic stroke: surgical validation and transcriptomic insights.

Chengji Wang, Hainan Yang, Hui Ye, Weifang Yuan, Haikuo Wang, Xueru Huang, Lingjuan Wu, Meichen Liu, Jing Wang, Ruling Shen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chengji WangShanghai Laboratory Animal Research Center Shanghai 201203, China.
Hainan YangDepartment of Critical Care Medicine, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine Shanghai 200137, China.
Hui YeDepartment of Critical Care Medicine, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine Shanghai 200137, China.
Weifang YuanDepartment of Critical Care Medicine, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine Shanghai 200137, China.
Haikuo WangDepartment of Critical Care Medicine, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine Shanghai 200137, China.
Xueru HuangDepartment of Critical Care Medicine, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine Shanghai 200137, China.
Lingjuan WuSchool of Pharmacy, Shanghai University of Medicine and Health Sciences Shanghai 201318, China.
Meichen LiuSchool of Pharmacy, Shanghai University of Medicine and Health Sciences Shanghai 201318, China.
Jing WangSchool of Pharmacy, Shanghai University of Medicine and Health Sciences Shanghai 201318, China.
Ruling ShenShanghai Laboratory Animal Research Center Shanghai 201203, China.
Weikui FengDepartment of Neurology, Mian County Hospital Hanzhong 724200, Shaanxi, China.
Xiaoming XinSchool of Pharmacy, Shanghai University of Medicine and Health Sciences Shanghai 201318, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIschemic stroke (IS) is a leading cause of death and long-term disability worldwide. Rodent models, particularly mice and rats, are widely used to investigate its underlying mechanisms. The

methodsWe established an MCAO model in

resultsThe model demonstrated a significant reduction in CBF (58.86%, P < 0.001) and clear neurological deficits. A total of 1,707 DEGs were identified, including 1,379 upregulated and 328 downregulated genes, which were primarily enriched in immune and inflammatory pathways. Key genes (CCL4, LIF, IL6, and OSM [upregulated]; LOC126493158 and LOC126489791 [downregulated]) were successfully validated.

conclusion

Indexed as

gene expression profileIschemic strokeMCAO modelMicrotus fortistranslational medicine

Identifiers

PMID42630654
PMCPMC13494413

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.