Evidence map›Paper›PMID 42630638›Full record

ReviewFrontiers in pharmacology2026

Amphetamine-type stimulants in young adults with ADHD: effects on sleep, circadian rhythms, and neuropsychiatric outcomes.

Amelia Hanshaw, Alexandria Shanks, Alessandra Porcu

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Amelia HanshawDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, United States.
Alexandria ShanksDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, United States.
Alessandra PorcuDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, United States.

Funding

Neurobiological responses of somatostatin neuronal circuits to environmental light disruptions during pubertal developmentR01AT013234 · NCCIH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Alessandra Porcu · 2025 to 2026
$1.0M
Effects of light exposure on amygdala plasticity during adolescence: implications for anxiety and well-beingR00AT010903 · NCCIH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI PORCU, ALESSANDRA · 2022 to 2024
$742k
Effects of light exposure on amygdala plasticity during adolescence: implications for anxiety and well-beingK99AT010903 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PORCU, ALESSANDRA · 2021 to 2022
$168k
NCCIH NIH HHS K99 AT010903NCCIH NIH HHS R00 AT010903NCCIH NIH HHS R01 AT013234
6 · The paper itself

Abstract

Amphetamine-type stimulants are widely prescribed for the treatment of attention-deficit/hyperactivity disorder (ADHD) and are commonly used by college-aged individuals. While effective for improving attention and executive function, these medications may also influence sleep and circadian regulation. College students are particularly vulnerable to sleep disturbances because young adulthood is characterized by a biologically delayed circadian phase that favors later sleep timing. Combined with academic and social demands and nighttime light exposure, as well as the high prevalence of delayed circadian rhythms in ADHD, these factors may increase susceptibility to circadian misalignment and sleep disruption. This mini-review provides a narrative synthesis of the current literature examining the relationship between amphetamine-type stimulant use, sleep and circadian dysregulation, and neuropsychiatric outcomes in young adults with ADHD. Understanding how stimulant pharmacology interacts with the circadian system and sleep may help optimize treatment strategies and reduce side effects in young adults with ADHD.

Indexed as

ADHDamphetaminechronotypecircadian rhythmsmelatoninpsychosissleepstimulants

Identifiers

PMID42630638
PMCPMC13494383

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.