ArticleFrontiers in neurology2026
Convergent 3-6 kHz cochlear vulnerability in aircrew: matching threshold sound conditioning targets to operational flight profiles.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Commercial and military aircrew operate within a multi-hazard auditory environment that combines cabin acoustic noise, chronic hypobaric hypoxia under regulatory cabin-pressure caps, and altitude-dependent cosmic ionizing radiation. Their convergent action on cochlear vulnerability has not been quantified, and no decision framework exists for matching threshold sound conditioning (TSC) target frequencies to operational flight profiles. This work is a computational, hypothesis-generating framework rather than an empirical study. We propose that the dominant frequency band of cochlear vulnerability in aircrew (3-6 kHz) emerges as the geometric overlap of three mechanism-distinct vulnerability kernels and coincides with the TSC selection region (3, 4 or 6 kHz) evaluated in the Kwak and Kwak 2020 randomized controlled trial. We construct a Cumulative Cochlear Stress Index (CCSI) that combines a CARI-7-derived radiation dose formula, an estimated-alveolar-tension hypoxia term and an A-weighted noise term, weighted by frequency-resolved Gaussian vulnerability kernels in log-octave space. The geometric mean of the three kernels peaks at
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