Observational study on the application of different esketamine gargle doses for the prevention of postoperative sore throat after laryngeal mask airway insertion.

Background: Ketamine gargle is considered a highly effective measure for preventing postoperative sore throat (POST). This randomized controlled study aimed to explore the efficacy, safety, and optimal dosage of esketamine gargle for preventing POST following laryngeal mask airway insertion. Methods: A total of 150 patients were randomly assigned to receive normal saline (NS), 25 mg, or 50 mg of esketamine gargle at a 1:1:1 ratio for 30 s prior to general anesthesia. The primary outcomes were the incidence of POST at 2, 6, and 24 h postoperatively. The secondary outcomes included the severity of POST at 2, 6, and 24 h postoperatively, along with the incidence and severity of dysphagia and hoarseness. Other outcomes included the incidence of the first intubation attempt, repositioning during surgery, convert to tracheal intubation, SpO Results: The incidence of POST at 2, 6, and 24 h postoperatively was 32%, 10%, and 12%; 22%, 8%, and 8%; and 12%, 6%, and 4%, respectively, with a statistically significant difference among groups at 2 h postoperatively ( Conclusion: Esketamine gargle is effective and safe for preventing POST following laryngeal mask airway insertion, and a dose of 25 mg is recommended. Clinical Trial Registration: ChiCTR2500099787.