ArticleFrontiers in pharmacology2026
Microphysiological modeling of the Blood-CSF barrier for biopharmaceutical transport and sequestration: evaluation of PEG-induced accumulation and vacuolation in the choroid plexus epithelium.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: It has long been established that the central nervous system (CNS) is a highly privileged space, with the blood-brain barrier (BBB) acting as the gatekeeper that allows or denies access to the brain by nutrients, drugs, and toxins. The BBB, however, is not the only barrier at play. The barrier between blood and cerebrospinal fluid (CSF) also has a critical role in guarding and feeding the CNS, but despite its importance, the blood-CSF barrier (BCSFB) remains relatively unexplored compared to the BBB, particularly with regard to models that do not rely on animals. Methods: Given the lack of physiologically relevant Results: By leveraging advanced microfluidic organ chip design and gravity perfusion, we have generated a hBCSFB organ chip that recapitulates many of the physiologically relevant characteristics of this barrier, including junctional protein expression, permeability less than 1.55e-5 cm/s, transcytosis that showed dose-dependent accumulation of 10%-35%, and selective transport that was both statistically significant (p ≤ 0.05) and reproducible. Conclusion: Having achieved these benchmarks and validated their reproducibility, this work provides a useful
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