Evidence map›Paper›PMID 42630513›Full record

ArticlePathology oncology research : POR2026

SPOCK1 overexpression suggests poor prognosis in head and neck squamous cell carcinomas.

Noemi Piroska Jakob, Matyas Majoros, Imre Uri, Helga Szakadati, Ede Birtalan, Kornelia Baghy, Zoltan Kelemen, Laszlo Tamas, Kornel Danos, Tibor Krenacs

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Article in Pathology oncology research : POR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Noemi Piroska JakobDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Matyas MajorosDepartment of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary.
Imre UriDepartment of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary.
Helga SzakadatiDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Ede BirtalanDepartment of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary.
Kornelia BaghyDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Zoltan KelemenDepartment of Oro-Maxillofacial Surgery and Stomatology, Faculty of Dentistry, Semmelweis University, Budapest, Hungary.
Laszlo TamasDepartment of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary.
Kornel DanosDepartment of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary.
Tibor KrenacsDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck squamous cell carcinomas (HNSCCs) are mostly associated with smoking, alcohol intake, and/or human papillomavirus HPV16 and/or HPV18 infection. However, most tumors are diagnosed at an advanced stage. In the search for biomarkers of HNSCC, we studied the prognostic role of SPOCK1, a heparan sulfate proteoglycan. In HNSCC, SPOCK1 expression was tested both at

Indexed as

Biomarkers, TumorCarcinoma, Squamous CellHead and Neck NeoplasmsProteoglycansAgedFemaleHumansMaleMiddle AgedPrognosisRNA, MessengerSquamous Cell Carcinoma of Head and NeckSurvival RateBiomarkers, TumorProteoglycansRNA, MessengerSPOCK1 protein, humanhead and neck squamous cell carcinomaimmunohistochemistrymRNA expressionprognostic biomarkerSPOCK1 proteoglycan

Identifiers

PMID42630513
PMCPMC13494527

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.