Evidence map›Paper›PMID 42630503›Full record

Observational studyOncology research2026

On-Treatment Grade 3-4 Neutropenia and Clinical Outcomes with Trifluridine/Tipiracil in Refractory Metastatic Colorectal Cancer: ReTrITA Real-World Evidence.

Carlo Signorelli, Michele Basso, Annunziato Anghelone, Maria Alessandra Calegari, Alessandro Passardi, Chiara Gallio, Alessandro Bittoni, Jessica Lucchetti, Lorenzo Angotti, Emanuela Di Giacomo and 19 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Oncology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Carlo SignorelliMedical Oncology Unit, S. Rosa Hospital, ASL Viterbo, Viterbo, Italy.ORCID https://orcid.org/0000-0001-9710-4962
Michele BassoOncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Rome, Italy.
Annunziato AngheloneOncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Rome, Italy.ORCID https://orcid.org/0009-0003-2647-2110
Maria Alessandra CalegariOncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0001-6856-2593
Alessandro PassardiDepartment of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.ORCID https://orcid.org/0000-0002-7099-240X
Chiara GallioDepartment of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.ORCID https://orcid.org/0009-0003-7380-1255
Alessandro BittoniDepartment of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.ORCID https://orcid.org/0000-0002-4056-0067
Jessica LucchettiDivision of Medical Oncology, Policlinico Universitario Campus Bio-Medico, Rome, Italy.ORCID https://orcid.org/0000-0002-0262-535X
Lorenzo AngottiDivision of Medical Oncology, Policlinico Universitario Campus Bio-Medico, Rome, Italy.ORCID https://orcid.org/0009-0002-8378-2943
Emanuela Di GiacomoDivision of Medical Oncology, Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Ina Valeria ZurloMedical Oncology, "Vito Fazzi" Hospital, Lecce, Italy.ORCID https://orcid.org/0000-0002-8876-4691
Cristina MorelliMedical Oncology Unit, Department of Systems Medicine, Tor Vergata University Hospital, Rome, Italy.
Emanuela Dell'AquilaIRCCS Regina Elena National Cancer Institute, Rome, Italy.ORCID https://orcid.org/0000-0002-7258-1364
Adele ArtemiIRCCS Regina Elena National Cancer Institute, Rome, Italy.
Donatello GemmaMedical Oncology Unit, ASL Frosinone, Sora, Italy.
Domenico Cristiano CorsiMedical Oncology, Isola Tiberina Hospital, Gemelli Isola, Rome, Italy.ORCID https://orcid.org/0000-0002-5017-6704
Alessandra EmilianiMedical Oncology, Isola Tiberina Hospital, Gemelli Isola, Rome, Italy.
Marta RibelliMedical Oncology, Isola Tiberina Hospital, Gemelli Isola, Rome, Italy.
Federica MazzucaDepartment of Clinical and Molecular Medicine, Oncology Unit, Sant' Andrea University Hospital, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0002-6580-286X
Giulia ArriviDepartment of Clinical and Molecular Medicine, Oncology Unit, Sant' Andrea University Hospital, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0003-0541-415X
Federica ZorattoUOC Oncologia, Ospedale Santa Maria Goretti, ASL Latina, Latina, Italy.ORCID https://orcid.org/0000-0001-8387-1968
Maria Grazia MorandiMedical Oncology Unit, San Camillo de Lellis Hospital, ASL Rieti, Rieti, Italy.
Fiorenza SantamariaUOC Oncology A, Policlinico Umberto I, Rome, Italy.ORCID https://orcid.org/0000-0002-1214-9342
Manuela DettoriMedical Oncology Department, Ospedale Oncologico Armando Businco, Cagliari, Italy.
Antonella CosimatiMedical Oncology Department, UO Oncologia Universitaria della Casa della Salute di Aprilia, Aprilia, Italy.ORCID https://orcid.org/0000-0002-2636-3198
Rosa SaltarelliUOC Oncology, San Giovanni Evangelista Hospital, ASL RM5, Tivoli, Italy.
Alessandro MinelliMedical Oncology Dept., UO Oncologia, Ospedale San Paolo, ASL RM4, Civitavecchia, Italy.
Emanuela Lucci-CordiscoUOC Genetica Medica, Dipartimento di Scienze della Vita e Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0002-6279-7604
Mario Giovanni ChilelliMedical Oncology Unit, S. Rosa Hospital, ASL Viterbo, Viterbo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsColorectal NeoplasmsNeutropeniaPyrrolidinesThymineTrifluridineUracilAdultAgedDrug CombinationsFemaleHumansMaleMiddle AgedNeoplasm MetastasisPrognosisDrug CombinationsPyrrolidinesThymineTrifluridinetrifluridine tipiracil drug combinationUracilmetastatic colorectal cancerneutropeniaprognostic biomarkersreal-world evidencesurvival outcomesTrifluridine/tipiracil

Identifiers

PMID42630503
PMCPMC13494493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.