ArticleAmerican journal of translational research2026
Serum HMGB1 and CA19-9 are independently associated with pulmonary cavity formation in patients with non-tuberculous mycobacterial pulmonary disease.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis work aimed to investigate the changes in serum inflammatory factors (IFs) in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) and to analyze their correlation with the presence of lung cavities.
methodsA retrospective study was conducted on 80 NTM-PD patients and 80 non-active pulmonary tuberculosis (Non-ATB) controls. Clinical characteristics, NTM species distribution, and chest CT findings were analyzed. Serum levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), procalcitonin (PCT), interleukin-1 (IL-1), IL-6, IL-8, high mobility group box protein 1 (HMGB1), Cystatin C (Cys C), and carbohydrate antigen 19-9 (CA 19-9) were measured by ELISA. Correlations between IFs and cavitation were assessed using Spearman's test.
resultsCavitation on CT was present in 31.2% of NTM-PD patients. Compared to Non-ATB controls, NTM-PD patients showed significantly higher levels of CRP, TNF-α, IL-6, HMGB1, Cys C, and CA19-9 (all
conclusionsSerum HMGB1 and CA19-9 were independently associated with lung cavitation in NTM-PD patients and, together with CRP, may serve as non-invasive biomarkers for disease severity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.