ArticleFrontiers in medicine2026
ILM flap coverage versus conventional ILM peeling for idiopathic full-thickness macular hole: a retrospective cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Background: Idiopathic full-thickness macular hole (iFTMH) is treated by pars plana vitrectomy with internal limiting membrane (ILM) peeling. Conventional peeling achieves high closure in small holes but may yield inferior closure morphology in larger lesions. The temporal inverted ILM flap technique may improve closure quality, yet observational data stratified by Type 1 versus Type 2 closure require careful handling of baseline imbalance. Methods: We conducted a retrospective cohort study of 202 consecutive iFTMH eyes from 202 unique patients operated by a single team between January 2022 and December 2024. The strict primary-endpoint cohort comprised 198 eyes with 12-month OCT within a prespecified ± 4-week window (flap, Results: The flap group had larger baseline holes, worse baseline BCVA, and longer symptom duration (all Conclusion: In this retrospective single-center cohort with predominantly large iFTMH, temporal inverted ILM flap coverage was associated with a higher adjusted probability of Type 1 closure at 12 months than conventional ILM peeling within an overlap-population estimand. Exploratory secondary functional and microstructural findings should be interpreted as hypothesis-generating associations rather than confirmatory evidence.
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