Evidence map›Paper›PMID 42630359›Full record

ArticleiMeta2026

Spatial multi-omics unveils sphingolipid metabolic reprogramming within the retinal pathological niche.

Yunhong Shi, Jinpei Lin, Yi Wu, Shengsong Xu, Naiyuan Zhang, Yiji Pan, Anli Ren, Ying Fang, Yu Huang, Xiayin Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iMeta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yunhong ShiGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.ORCID https://orcid.org/0000-0003-2697-9045
Jinpei LinCollege of Life Sciences University of Chinese Academy of Sciences Beijing China.ORCID https://orcid.org/0009-0002-5163-2895
Yi WuGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Shengsong XuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology Visual Science Guangzhou China.
Naiyuan ZhangGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Yiji PanGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Anli RenGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Ying FangGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.
Yu HuangDepartment of Eye and Vision Sciences, Institute of Life Course and Medical Sciences University of Liverpool Liverpool UK.
Xiayin ZhangSingapore Eye Research Institute Singapore National Eye Center Singapore Singapore.
Zhuoting ZhuCentre for Eye Research Australia, University of Melbourne, Department of Surgery (Ophthalmology) University of Melbourne Melbourne Australia.
Yehong ZhuoState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology Visual Science Guangzhou China.
Honghua YuJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong Shantou China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinal ischemia-reperfusion (RIR) injury is a central mechanism underlying irreversible vision loss in glaucoma and other retinal diseases, yet the spatial organization of the pathogenic microenvironment remains poorly understood. Here, we constructed a high-resolution, whole-eye spatial multi-omics atlas integrating Stereo-seq transcriptomics and MALDI-MSI-based metabolomics to capture the early molecular events in the RIR mouse model. Spatially, retinal ganglion cell (RGC) interactions with surrounding cells were markedly reduced after injury, whereas immune-glial interactions were enhanced, revealing a shift from a neuron-centered to an immunometabolic state. Within the ganglion cell layer (GCL), the primary pathological locus, we identified

Indexed as

immunometabolic remodelingretinal ischemia‐reperfusionspatial metabolomicsspatial transcriptomicsTrem2+ microglia

Identifiers

PMID42630359
PMCPMC13494123

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.