Evidence map›Paper›PMID 42630346›Full record

ArticleRare tumors2026

Pulmonary carcinoid harboring a

Kosuke Hamai, Masaaki Abe, Shinya Miyake, Ryo Katsura, Nana Kozuki, Akinori Shimizu, Masahiro Nakahara, Keiji Hanada, Shuji Yonehara, Takao Hinoi

Abstract readCase Reports
In one paragraph

Article in Rare tumors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kosuke HamaiDepartment of Respiratory Medicine, JA Onomichi General Hospital, Onomichi, Japan.ORCID https://orcid.org/0000-0002-8654-5532
Masaaki AbeDepartment of Respiratory Medicine, JA Onomichi General Hospital, Onomichi, Japan.
Shinya MiyakeDepartment of Respiratory Medicine, JA Onomichi General Hospital, Onomichi, Japan.
Ryo KatsuraDepartment of Respiratory Medicine, JA Onomichi General Hospital, Onomichi, Japan.
Nana KozukiDepartment of Respiratory Medicine, JA Onomichi General Hospital, Onomichi, Japan.
Akinori ShimizuDepartment of Genetic Medicine, JA Onomichi General Hospital, Onomichi, Japan.
Masahiro NakaharaDepartment of Genetic Medicine, JA Onomichi General Hospital, Onomichi, Japan.
Keiji HanadaDepartment of Genetic Medicine, JA Onomichi General Hospital, Onomichi, Japan.
Shuji YoneharaDepartment of Pathology, JA Onomichi General Hospital, Onomichi, Japan.
Takao HinoiDepartment of Genetic Medicine, JA Onomichi General Hospital, Onomichi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary carcinoids are the pulmonary counterparts of gastrointestinal neuroendocrine tumors (NETs) G1-2. They may cause distant metastasis, leading to a poor prognosis, and requiring chemotherapy. Reports on cases harboring driver gene mutations remain limited. A man in his late 60s visited to JA Onomichi General Hospital because he was suspected of lung cancer. Positron emission tomography/computed tomography (PET/CT) showed a 24-mm nodule in the right upper lobe with abnormal ^18F-fluorodeoxyglucose uptake, and bronchoscopic examination revealed adenocarcinoma. Surgery was planned for stage IA3 lung adenocarcinoma; however, intraoperative findings demonstrated pleural dissemination, and the procedure was terminated as an exploratory thoracotomy. Pathological examination of tissue obtained from the pleural dissemination showed features consistent with NET G2, confirming a diagnosis of atypical carcinoid. Ten months after treatment with carboplatin plus etoposide, salvage surgery consisting of right upper lobectomy and resection of pleural dissemination was performed. Histopathological examination revealed a papillary adenocarcinoma adjacent to a NET G2. Three months after surgery, CT revealed a metastatic lesion in the retrohepatic segment. Histological examination of the liver tumor obtained via laparoscopic hepatectomy confirmed a NET G2 without adenocarcinomatous components. Four months after hepatectomy, PET/CT demonstrated multiple lymph node metastases. The patient was treated sequentially with carboplatin plus etoposide, everolimus, and amrubicin, however, the liver metastases progressed. A liver tumor biopsy was performed for comprehensive genomic profiling (CGP). The biopsy specimen revealed metastatic NET G2. FoundationOne CDx testing identified

Indexed as

comprehensive genomic profilingKRAS G12Cneuroendocrine tumorpulmonary carcinoidsotorasib

Identifiers

PMID42630346
PMCPMC13494277

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