ArticleFrontiers in medicine2026
Adjunctive Chaihu Guizhi Tang combined with Maxing Shigan Tang and short-term clinical recovery in hospitalized older adults with community-acquired pneumonia: a prospective non-randomized controlled study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Older adults hospitalized with community-acquired pneumonia (CAP) often recover slowly despite standard care. Chaihu Guizhi Tang combined with Maxing Shigan Tang (CHGZ + MXSG) is used as adjunctive traditional Chinese medicine for respiratory infections, but prospective evidence in older inpatients is limited. We evaluated its association with short-term clinical recovery. Methods: In this open-label prospective non-randomized controlled study, 186 older adults hospitalized with CAP received adjunctive CHGZ + MXSG plus standard care ( Results: Day-7 clinical cure occurred in 74 of 93 participants (79.6%) in the CHGZ + MXSG group and 58 of 93 participants (62.4%) in the standard-care group [unadjusted risk ratio 1.28, 95% confidence interval (CI) 1.06 to 1.54; Conclusion: Among hospitalized older adults with CAP, adjunctive CHGZ + MXSG plus standard care was associated with faster short-term clinical recovery and no descriptive excess of the prespecified safety events. Because treatment allocation was not randomized and outcome assessment was open-label, these findings should be interpreted as adjusted associations rather than definitive causal effects and should be evaluated in adequately powered randomized or pragmatic trials.
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