ArticleFrontiers in pediatrics2026
Analysis of risk factors for severe acute poisoning in children.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To identify independent risk factors for the progression of acute poisoning to severe cases in children, and to provide a basis for early clinical identification and intervention. Methods: A retrospective study was conducted to collect the clinical data of hospitalized children with acute poisoning at Tianshui First People's Hospital from January 1, 2018 to December 31, 2025. According to the Poisoning Severity Score (PSS), patients were divided into the severe group (≥3 points) and the non-severe group (<3 points). Variables that were statistically significant in univariate analysis were included in binary logistic regression analysis to identify independent risk factors for severe poisoning. Results: A total of 726 children with acute poisoning were enrolled, including 79 (10.9%) severe cases and 647 (89.1%) non-severe cases Conclusions: Gastric lavage associated with a lower risk of severe poisoning in this pediatric cohort. When strictly indicated, it may remain a procedure of clinical value. Left-behind children and those with self-poisoning are high-risk populations requiring enhanced family supervision, early recognition, and psychological intervention. The association between antidote use and increased risk of severe poisoning likely reflects confounding by indication, and should not delay necessary antidotal therapy.
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