ArticleFrontiers in cellular and infection microbiology2026
The diagnostic value of platelet-related indicators to CRP ratio in periprosthetic joint infection.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the diagnostic value of platelet-to-CRP ratios for periprosthetic joint infection (PJI) following total joint arthroplasty, and to assess the influence of potential confounders. Methods: A retrospective case-control study included 151 PJI patients and 178 with aseptic loosening (AL). CRP, ESR, PLT, PDW, PLT/CRP, PLT/ESR, and PDW/CRP were compared between groups. ROC curves assessed diagnostic performance. Subgroup analyses stratified by joint (hip/knee) and infection duration (acute/chronic) were performed. Multivariate regression adjusted for time-related covariates, with pairwise ROC comparisons via DeLong test. Results: Joint distribution, symptom duration, diabetes, and time from arthroplasty differed significantly between groups (all Conclusion: PLT/CRP and PDW/CRP are low-cost adjunctive biomarkers for PJI diagnosis, with PDW/CRP offering well-balanced sensitivity and specificity. Their diagnostic performance is stable across hip and knee joints and independent of symptom duration or implantation time. External validation in unselected populations is warranted.
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