ArticleFrontiers in medicine2026
Prior COVID-19 infection and fibromyalgia criteria fulfillment: a comparative cross-sectional study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Background: Fibromyalgia (FM) is a chronic widespread pain syndrome frequently accompanied by fatigue, cognitive dysfunction, psychological symptoms, and multiple somatic symptoms. Coronavirus disease 2019 (COVID-19) has affected millions worldwide; however, its long-term sequelae remain incompletely understood. Objective: This study aimed to investigate whether prior COVID-19 infection was associated with a higher prevalence of fibromyalgia and to identify demographic and clinical factors associated with fibromyalgia in the study population. Subjects and methods: This comparative cross-sectional study included 250 individuals with PCR-confirmed COVID-19 at least 3 months before assessment and 250 participants without a known history of confirmed COVID-19 infection. Data were collected at a single time point using a structured questionnaire and interview. Fibromyalgia status was defined as fulfillment of the modified 2016 American College of Rheumatology criteria. Results: Fibromyalgia criteria were fulfilled by 60/250 participants (24.0%) with prior COVID-19 infection compared with 35/250 participants (14.0%) in the comparison group. In crude analysis, prior COVID-19 infection was associated with higher odds of fibromyalgia criteria fulfillment (OR = 1.94, 95% CI: 1.22-3.07, Conclusion: Prior COVID-19 infection remained associated with higher odds of modified 2016 ACR fibromyalgia criteria fulfillment. Female sex and non-employment were also associated with fibromyalgia criteria fulfillment, highlighting the need for clinical awareness and early recognition of fibromyalgia-like symptoms among individuals with a history of COVID-19 infection.
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