Evidence map›Paper›PMID 42630198›Full record

ArticleFrontiers in endocrinology2026

Clinical and genetic evidence from East Asian cohorts linking family history burden and menarche timing to curve severity in adolescent idiopathic scoliosis.

Ryutaro Tanaka, Takuro Iwami, Yoshiro Yonezawa, Nao Otomo, Kazuki Takeda, Shiro Ikegawa, Morio Matsumoto, Masaya Nakamura, Kota Watanabe, Chikashi Terao

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Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Ryutaro TanakaDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Takuro IwamiDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Yoshiro YonezawaDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Nao OtomoDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Kazuki TakedaDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Shiro IkegawaLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Morio MatsumotoDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Masaya NakamuraDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Kota WatanabeDepartment of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
Chikashi TeraoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Adolescent idiopathic scoliosis (AIS) affects 2% to 3% of adolescents and progresses rapidly during puberty. Previous studies suggest that a positive family history of AIS and a later age at menarche (AAM) are risk factors for curve severity in AIS, but their quantitative evidence and the causal contribution of AAM remain to be elucidated. Methods: We analyzed 5,891 patients with AIS to evaluate the associations of family history and AAM with curve severity. Genetic correlation, Mendelian randomization, harmonized variant-level analyses, and variance component analyses were also performed. Results: Family history was associated with curve severity ( Discussion: This study provides quantitative genetic evidence linking family history of AIS and later AAM to curve severity. These findings support the use of family history and AAM in clinical settings to stratify patients according to the risk of greater curve severity.

Indexed as

MenarcheScoliosisAdolescentAsia, EasternChildCohort StudiesEast Asian PeopleFemaleGenetic Predisposition to DiseaseHumansMendelian Randomization AnalysisPolymorphism, Single NucleotideRisk FactorsSeverity of Illness IndexSpineadolescent idiopathic scoliosisage at menarcheCobb anglefamily historygenetic correlationgenetic predispositiongeneticsMendelian randomization

Identifiers

PMID42630198
PMCPMC13493220

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.