Dose-dependent reduction of optic nerve sheath diameter during graded lower body negative pressure in healthy adults of both sexes.

Andrej Bergauer, Janez Urevc, Bianca Steuber, Karin Schmid-Zalaudek, Vid Pivec, Nandu Goswami

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Article in Frontiers in network physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Andrej BergauerDivision of Physiology, Otto Loewi Research Center of Vascular Biology, Immunity and Inflammation, Medical University of Graz, Graz, Austria.

Janez UrevcFaculty of Mechanical Engineering, University of Ljubljana, Ljubljana, Slovenia.

Bianca SteuberDivision of Physiology, Otto Loewi Research Center of Vascular Biology, Immunity and Inflammation, Medical University of Graz, Graz, Austria.

Karin Schmid-ZalaudekDivision of Physiology, Otto Loewi Research Center of Vascular Biology, Immunity and Inflammation, Medical University of Graz, Graz, Austria.

Vid PivecDivision of Physiology, Otto Loewi Research Center of Vascular Biology, Immunity and Inflammation, Medical University of Graz, Graz, Austria.

Nandu GoswamiDivision of Physiology, Otto Loewi Research Center of Vascular Biology, Immunity and Inflammation, Medical University of Graz, Graz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Optic nerve sheath diameter (ONSD) measured by ultrasound provides a non-invasive surrogate of intracranial pressure. Although lower body negative pressure (LBNP) is widely used to simulate central hypovolemia, the dose-response relationship between graded LBNP and ONSD, and possible sex differences therein, are incompletely characterized. Methods: Forty-four healthy young adults (22 female, 22 male) underwent graded LBNP ( Results: A progressive and statistically significant reduction in ONSD was observed at every LBNP level in both sexes. Female participants showed reductions of approximately Conclusion: Graded LBNP induces a progressive, dose-dependent reduction in ONSD that is detectable already at mild LBNP (

Indexed as

cardiovascular physiologycentral hypovolemiaintracranial pressurelower body negative pressurenetwork physiologyoptic nerve sheath diametersex differencesultrasound

Identifiers

PMID42630170

DOI10.3389/fnetp.2026.1908460

PMCPMC13493247

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