ArticleFrontiers in endocrinology2026
Lack of association between Triglyceride glucose-body mass index and glomerular filtration rate in patients with coronary heart disease after percutaneous coronary intervention: a retrospective case-control study.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: There exists a close and complex bidirectional relationship between cardiovascular disease (CVD) and chronic kidney disease (CKD). CVD is a well-established risk factor for CKD, while the Triglyceride glucose-body mass index (TyG-BMI) has been considered as a predictor of cardiovascular events. This was a retrospective case-control study. This study aimed to investigate the relationship between preoperative TyG-BMI and estimated glomerular filtration rate(eGFR) during follow-up in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI). Methods: This study was performed in 1020 patients with CHD after PCI without CKD from 01/01/2015 to 01/01/2025. We performed multifaceted analyses of the association between preoperative TyG-BMI and eGFR, including multiple linear regression for continuous eGFR outcomes, logistic regression to identify whether TyG-BMI independently influenced categorical eGFR status and quantify the magnitude of this association, and restricted cubic spline (RCS) analysis to explore non-linear relationships. Low eGFR (<60 mL/(min*1.73m²)) was set as the outcome variable, and was obtained from the latest follow-up. Results: The multivariate linear regression analysis revealed no statistically significant linear association between preoperative TyG-BMI and eGFR ( Conclusion: Preoperative TyG-BMI exerted no direct independent effect on long-term outcome of eGFR. It is unlikely that TyG-BMI serves as a primary determinant of CKD in patients with CHD after PCI. Future studies should evaluate combined risk models.
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