Evidence map›Paper›PMID 42630074›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Aberrant ɑSMA expression reveals broad mossy fiber reorganization integrating with tangle and plaque formation and mitoenergetic alteration in the human hippocampus.

Tian Tu, Qi-Lei Zhang, Zhong-Ping Sun, Chao Kang, Dan Li, Xin-Hua Huo, Xiao-Jie Zhang, Yan Zhang, Mengchao Cui, Aihua Pan and 2 more

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Tian Tu *Department of Anatomy and Neurobiology, Central South University, Xiangya School of Basic Medical Sciences, Changsha, China.
Qi-Lei Zhang *Department of Anatomy and Neurobiology, Central South University, Xiangya School of Basic Medical Sciences, Changsha, China.
Zhong-Ping SunDepartment of Anatomy and Neurobiology, Central South University, Xiangya School of Basic Medical Sciences, Changsha, China.
Chao KangDepartment of Anatomy and Neurobiology, Central South University, Xiangya School of Basic Medical Sciences, Changsha, China.
Dan LiDepartment of Anatomy and Neurobiology, Central South University, Xiangya School of Basic Medical Sciences, Changsha, China.
Xin-Hua HuoThe Reproductive and Stem Cell Engineering Institute, Central South University, Xiangya School of Basic Medical Sciences, Changsha, China.
Xiao-Jie ZhangDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.
Yan ZhangDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.
Mengchao CuiKey Laboratory of Radiopharmaceuticals, Ministry of Education, Beijing Normal University, Beijing, China.
Aihua PanDepartment of Anatomy and Neurobiology, Central South University, Xiangya School of Basic Medical Sciences, Changsha, China.
Jian WangThe Reproductive and Stem Cell Engineering Institute, Central South University, Xiangya School of Basic Medical Sciences, Changsha, China.
Xiao-Xin YanDepartment of Anatomy and Neurobiology, Central South University, Xiangya School of Basic Medical Sciences, Changsha, China.

Funding

Ministry of Science and Technology of China #2021ZD0201103Ministry of Science and Technology of China #2021ZD02018National Natural Science Foundation of China #82201595
6 · The paper itself

Abstract

introductionNeural network and bioenergetic abnormalities occur with Alzheimer's disease (AD) pathogenesis.

methodsWe explored mossy fiber (MF) and mitoenergetic alteration using ɑ-smooth muscle actin (ɑSMA) and cytochrome c oxidase (COX) immunolabeling in human hippocampus relative to tangle and plaque formation by referring to Braak (0-VI) and Thal (0-5) staging scores.

resultsIn the brain group with Braak/Thal 0/0 scores (control), ɑSMA labeling occurred in CA3 and dentate gyrus. In groups with 1a to IV/0 and II to VI/1 to 5 scores, ɑSMA labeling appeared in CA2 to subiculum, with increased density in these and the dentate subregions. ɑSMA-labeled MF terminals infiltrated into ghost tangles co-expressing amyloidogenic markers and coexisted among β-secreatse-1 labeled neurites and amyloid beta plaques. COX immunolabeling was increased in CA2 to subiculum in the groups with 1a to IV/0 to 1 compared to 0/0. DISCUSSION: MF reorganization/dystrophy develops and integrates with tangle and plaque formation and mitoenergetic alteration in the human hippocampus.

Indexed as

ActinsAlzheimer DiseaseHippocampusMossy Fibers, HippocampalNeurofibrillary TanglesPlaque, AmyloidAgedAged, 80 and overElectron Transport Complex IVFemaleHumansMaleACTA2 protein, humanActinsElectron Transport Complex IVamyloid beta 42/40 ratioaxonal sproutingneuronal deathsynaptic pathologytrisynaptic circuit

Identifiers

PMID42630074
PMCPMC13498905

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