Evidence map›Paper›PMID 42630044›Full record

ArticleAging cell2026

Piezo1 Activation Rescues Anabolic Response to Mechanical Loading in Aged Bone via Connexin 43 Hemichannels.

Dezhi Zhao, Jiayue Fu, Han Liu, Shuting Liang, Mingming Song, Aining Zhang, Dong-En Wang, Qianjin Guo, You Zhang, Jiawei Wu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dezhi ZhaoSchool of Medicine, Northwest University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0000-0001-8249-8743
Jiayue FuKey Laboratory for Space Bioscience and Biotechnology, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, Shaanxi, China.
Han LiuSchool of Medicine, Northwest University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0009-0004-9137-8689
Shuting LiangKey Laboratory for Space Bioscience and Biotechnology, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, Shaanxi, China.
Mingming SongCollege of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
Aining ZhangSchool of Medicine, Northwest University, Xi'an, Shaanxi, China.
Dong-En WangKey Laboratory for Space Bioscience and Biotechnology, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, Shaanxi, China.
Qianjin GuoDivision of Endocrinology, Department of Medicine, Stanford University, Stanford, California, USA.ORCID https://orcid.org/0000-0002-0335-2381
You ZhangSchool of Medicine, Northwest University, Xi'an, Shaanxi, China.
Jiawei WuSchool of Medicine, Northwest University, Xi'an, Shaanxi, China.
Huiyun XuKey Laboratory for Space Bioscience and Biotechnology, School of Life Science and Technology, Northwestern Polytechnical University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0000-0002-4873-9934

Funding

National Natural Science Foundation of China 32301088National Natural Science Foundation of China 81772409Natural Science Foundation of Shaanxi Provincial Department of Education 23JK0688
6 · The paper itself

Abstract

Bone mechanosensitivity declines with age, resulting in a reduced anabolic response to mechanical stimulation. Although the mechanosensitive ion channel Piezo1 plays a critical role in bone mechanoresponsiveness, its mechanisms of mechanotransduction in aged bone remain incompletely understood. Here, we report that aged tibiae from 19-month-old male mice exhibit a blunted anabolic response to axial cyclic compressive loading or administration of the Piezo1 agonist Yoda1 alone. However, chemical activation of osteocytic Piezo1 by Yoda1 effectively rescues the anabolic response of aged cortical bone to mechanical loading. Mechanistically, Yoda1-induced Piezo1 activation promotes its co-localization with connexin 43 (Cx43) on the osteocyte membrane in response to mechanical stimulation. This Piezo1-Cx43 interaction enhances Cx43 hemichannel (HC) activity via the PI3K-Akt signaling pathway. Subsequent HC opening facilitates the release of the anabolic factor prostaglandin E

Indexed as

AgingBone and BonesConnexin 43Ion ChannelsAnimalsMaleMechanotransduction, CellularMiceOsteocytesPyrazinesStress, MechanicalThiadiazolesConnexin 43Ion ChannelsPiezo1 protein, mousePyrazinesThiadiazolesyoda-1aged tibiaeanabolismCx43 hemichannelmechanical loadingPiezo1

Identifiers

PMID42630044
PMCPMC13498897

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.