ArticleMicrobial biotechnology2026
Structure-Guided Extremophile Genome Mining Expands the PETase Landscape and Reveals PET-Hydrolysing True Lipase Lineages.
Article in Microbial biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Poly(ethylene terephthalate) (PET) hydrolases are enzymes primarily within the polyesterase-cutinase branch of the α/β-hydrolase superfamily, whereas the contribution of true lipases to PET hydrolysis remains poorly explored. Here, we report the genome mining results of 18,082 extremophilic microorganisms, combined with structural modelling, enzyme-substrate simulations and experimental validation, which enables the identification of PET-active true lipases. Two true lipases, Lip
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