Evidence map›Paper›PMID 42629579›Full record

ReviewNeurological research and practice2026

German guideline on neurosyphilis.

Matthias Klein, Klemens Angstwurm, Stefan Esser, Juliane Fazio, Katrin Hahn, Simone Scheithauer, Anja Potthoff, Lara Chilver-Stainer, Jörg Weber, Ricardo Niklas Werner and 2 more

Abstract readReview
In one paragraph

Review in Neurological research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matthias KleinDepartment of Neurology, Ludwig-Maximilians University Munich, Marchioninistr. 15, Munich, 81377, Germany. matthias.klein@med.uni-muenchen.de.
Klemens AngstwurmDepartment of Neurology, University of Regensburg, Regensburg, Germany.
Stefan EsserDepartment of Dermatology, University of Duisburg-Essen, Essen, Germany.
Juliane FazioLaboratory Krone, Bad Salzuflen, Germany.
Katrin HahnDepartment of Neurology Berlin, Charite University Medicine Berlin, Berlin, Germany.
Simone ScheithauerDepartment of Infection Control and Infectious Diseases, University Medical Center Goettingen, Göttingen, Germany.
Anja PotthoffCatholic Hospital Bochum, Bochum, Germany.
Lara Chilver-StainerDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland (CH), Bern, Germany.
Jörg WeberDepartment of Neurology, Hospital of Klagenfurt, Klagenfurt am Wörthersee, Austria.
Ricardo Niklas WernerDepartment of Dermatology, Venereology and Allergology, Charite Universitätsmedizin Berlin, Berlin, Germany.
Brigitte WildmannDepartment of Neurology, Heidelberg University, Heidelberg, Germany.
Matthias MaschkeGerman Society of Neurology (DGN), Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurosyphilis is a severe disease which can manifest with various clinical signs. The diagnosis can be challenging. Patients with positive syphilis serology and neurological or psychiatric symptoms should undergo cerebrospinal fluid (CSF) examination. The definite diagnosis is based on CSF findings, including evidence of inflammation, intrathecal production of treponemal antibodies (plus reactive non-treponema specific tests in the CSF). However, these criteria are not always fulfilled and a diagnosis of probable neurosyphilis may be established using less stringent diagnostic criteria. Treatment with intravenous penicillin or ceftriaxone is recommended for neurosyphilis. Here, a short version of the recommendations of the German guidelines on neurosyphilis that were published in 2026 is presented.

Identifiers

PMID42629579
PMCPMC13499315

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.